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首页> 外文期刊>Modern Pathology >Sinusoidal CD30-Positive Large B-Cell Lymphoma: A Morphologic Mimic of Anaplastic Large Cell Lymphoma
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Sinusoidal CD30-Positive Large B-Cell Lymphoma: A Morphologic Mimic of Anaplastic Large Cell Lymphoma

机译：正弦CD30阳性大B细胞淋巴瘤：间变性大细胞淋巴瘤的形态学模拟。

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Anaplastic large cell lymphoma (ALCL) has been recognized recently as a distinct clinicopathologic entity, restricted to a subset of CD30-positive diffuse large cell lymphomas of Tull lineage. Some of the characteristic features of ALCL, such as CD30 antigen expression and the presence of large pleomorphic lymphoid cells infiltrating lymph node sinuses, can be found rarely in diffuse large B-cell lymphomas. We collected 11 such cases, and their clinical, morphologic, and immunophenotypic features are reviewed. The age of the patients ranged from 36 to 82 years (mean, 63.2 years) with a male to female ratio of 1:1.2. All neoplasms were nodal with a sinusoidal infiltrative pattern, although four neoplasms also had foci of confluent growth. Eight tumors were composed predominantly of large pleomorphic cells with occasional Reed-Sternberg–like cells. The other three tumors had a higher proportion of large monomorphic lymphoid cells. Necrosis and admixed granulocytes were other common features. Immunophenotypically, all cases were positive for CD30 and CD20 or CD79a. All eight cases examined for anaplastic lymphoma kinase-1 immunoreactivity were negative. In situ hybridization for Epstein-Barr virus RNA was performed in eight cases; two were positive. Excluding one consultation case with no available clinical follow-up data, six patients died of the disease within 3 years and one had disease relapse within 1 year. We conclude that an unusual variant of diffuse large B-cell lymphoma can closely mimic ALCL. However, these neoplasms can be distinguished from ALCL by virtue of their B-lineage and lack of anaplastic lymphoma kinase-1 expression. Evidence of Epstein-Barr virus infection can be found in a small subset of these neoplasms.
机译：间变性大细胞淋巴瘤（ALCL）最近被认为是一种独特的临床病理学实体，仅限于T / n谱系的CD30阳性弥漫性大细胞淋巴瘤的一个子集。在弥漫性大B细胞淋巴瘤中很少发现ALCL的某些特征，例如CD30抗原表达和浸润淋巴结窦的大型多形淋巴样细胞。我们收集了11个此类病例，并对其临床，形态和免疫表型特征进行了综述。患者年龄为36至82岁（平均63.2岁），男女之比为1：1.2。所有肿瘤均为淋巴结浸润型，尽管四个肿瘤也有融合生长灶。八个肿瘤主要由大型多形细胞组成，偶有里德-斯特恩伯格样细胞。其他三个肿瘤的大型单形淋巴样细胞比例更高。坏死和混合的粒细胞是其他常见特征。免疫表型上，所有病例CD30和CD20或CD79a均为阳性。检查的间变性淋巴瘤激酶-1免疫反应的所有八例均为阴性。在8例中进行了爱泼斯坦-巴尔病毒RNA的原位杂交。两个是积极的。排除一例没有可用临床随访数据的咨询病例，六名患者在3年内死于该病，一例在1年内复发。我们得出结论，弥漫性大B细胞淋巴瘤的不寻常变体可以紧密模拟ALCL。但是，这些肿瘤可以通过其B谱系和缺乏间变性淋巴瘤激酶1表达来区别于ALCL。在这些肿瘤的一小部分中可以找到爱泼斯坦-巴尔病毒感染的证据。

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