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Radical prostatectomy for carcinoma of the prostate

机译：前列腺癌根治性前列腺切除术

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Morphologic features of prostatic adenocarcinoma in the radical prostatectomy (RP) specimen are powerful prognostic indicators for prognosis for disease-free survival. This review discusses the methods of sampling of the RP specimen to optimize the detection of these morphologic features, balanced against the added expense of submitting the entire gland for sectioning. Gleason grade, one of the most powerful prognostic factors, is discussed briefly, including the percent pattern 4/5 cancer compared to the standard Gleason grading. Pathologic stage, as defined by the TNM system, is discussed in detail, both in terms of precise histological definition of each category, as well as the associated prognostic implications. Surgical margin status is also important prognostically across all pathologic stages categories. Perineural invasion, which has been used diagnostically in prostate cancer for several decades, has emerged as a very important prognostic indicator as well, as determined by the quantitative aspects of tumor in the perineural space. The effect of tumor volume on prognosis is discussed, as well as the newer concepts of the prognostic significance of zone of origin of the tumor and the presence or absence of intraductal carcinoma.
机译：前列腺癌根治术（RP）标本中前列腺腺癌的形态学特征是无病生存预后的有力预后指标。这篇综述讨论了RP样品取样的方法，以优化对这些形态特征的检测，并与将整个腺体进行切片所增加的费用进行了平衡。简要讨论了格里森分级，这是最有力的预后因素之一，其中包括与标准格里森分级相比的4/5癌症百分率。根据每个类别的精确组织学定义以及相关的预后意义，详细讨论了TNM系统定义的病理分期。在所有病理阶段类别中，手术切缘状态对预后也很重要。经神经周浸润已被诊断用于前列腺癌已有数十年之久，它也已成为非常重要的预后指标，这取决于肿瘤在神经周间隙中的定量方面。讨论了肿瘤体积对预后的影响，以及有关肿瘤起源区和导管内或不存在导管内预后意义的较新概念。

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