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首页> 外文期刊>Modern Pathology >Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma
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Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma

机译：不同组织学类型卵巢癌的端粒长度，以透明细胞癌为重点

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Ovarian carcinoma is composed of a heterogeneous group of tumors with distinct clinico-pathological and molecular features. Alteration of telomerase activity has been reported in ovarian tumors but the pattern of telomere length in their specific histological subtypes has not been reported. In this study, we performed quantitative telomere fluorescence in situ hybridization on a total of 219 ovarian carcinomas including 106 high-grade serous carcinomas, 26 low-grade serous carcinomas, 56 clear cell carcinomas and 31 low-grade endometrioid carcinomas. The mean relative telomere length of carcinoma to stromal cells was calculated as a telomere index. This index was significantly higher in clear cell carcinoma compared with the other histologic types (P=0.007). Overall there was no association between the telomere index and mortality, but when stratified by histologic types, the hazard ratio for death among women with clear cell carcinoma with a telomere index >1 was significantly increased at 4.93 (95% CI 1.64–14.86, P=0.005) when compared with those with a telomere index ≤1. In conclusion, our results provide new evidence that telomere length significantly differs by histologic type in ovarian carcinoma. Specifically, clear cell carcinomas have longer mean relative telomere lengths compared with the other histologic types and longer telomeres in clear cell carcinoma are associated with increased mortality suggesting that aberrations in telomere length may have an important role in the development and progression of this neoplasm.
机译：卵巢癌由具有不同临床病理和分子特征的异类肿瘤组成。在卵巢肿瘤中已经报道了端粒酶活性的改变，但是尚未报道其特定组织学亚型中端粒长度的模式。在这项研究中，我们对219种卵巢癌进行了端粒荧光原位杂交，其中包括106例高度浆液性癌，26例低度浆液性癌，56例透明细胞癌和31例低度子宫内膜样癌。计算癌与基质细胞的平均相对端粒长度作为端粒指数。与其他组织学类型相比，该指标在透明细胞癌中明显更高（P = 0.007）。总体而言，端粒指数与死亡率之间没有关联，但是按组织学类型分层时，端粒指数> 1的透明细胞癌女性的死亡危险比显着增加，为4.93（95％CI 1.64–14.86，与端粒指数≤1的那些相比，P = 0.005）。总之，我们的结果提供了新的证据，表明卵巢癌的端粒长度因组织学类型而异。具体而言，与其他组织学类型相比，透明细胞癌的平均相对端粒长度更长，而透明细胞癌中的端粒更长与死亡率增加相关，这表明端粒长度的异常可能在这种肿瘤的发生和发展中起重要作用。

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