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首页> 外文期刊>Modern Pathology >Expression of Bax and Apoptosis-Related Proteins in Human Esophageal Squamous Cell Carcinoma Including Dysplasia
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Expression of Bax and Apoptosis-Related Proteins in Human Esophageal Squamous Cell Carcinoma Including Dysplasia

机译：Bax和凋亡相关蛋白在包括不典型增生在内的人食道鳞状细胞癌中的表达

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The rate of tumor growth depends on the balance between proliferation and death of tumor cells. It is known that Bax, caspase-3, and p53 proteins are death-promoting factors, whereas Bcl-2 protein is a death antagonist. We immunohistochemically examined the expression of Bax and apoptosis-related proteins such as caspase-3, p53, and Bcl-2 in 76 patients with human esophageal squamous cell carcinoma (SCC) including dysplasia to determine the relationship of expression of each protein to tumor behavior and patients' prognosis. No significant relationships in immunopositivity were found among these proteins in SCCs. Cytoplasmic Bax expression was exhibited in 63 cases of SCCs (82.9%). The apoptotic index of caspase-3-positive lesions was significantly higher than that of caspase-3-negative lesions in both dysplasia and SCC (P = .016, P = .012). On the other hand, the apoptotic index (1.18%) was significantly correlated with Bax overexpression in dysplasia (P = .006), but not in SCC lesions (P = .129). The patients with Bax-positive SCCs were found to have a poor prognosis by the Kaplan-Meier method (P = .043). These findings suggested that Bax expressed in dysplasia may play a role as an apoptotic factor, but that it may be functionally inactive in some cancerous lesions and thus not contribute to suppression of the tumor progression in some cases of human esophageal SCCs.
机译：肿瘤的生长速率取决于肿瘤细胞的增殖与死亡之间的平衡。众所周知，Bax，caspase-3和p53蛋白是促死亡因子，而Bcl-2蛋白是促死亡因子。我们采用免疫组织化学方法检测了76例食管鳞状细胞癌（SCC）患者（包括发育异常）中Bax和凋亡相关蛋白（如caspase-3，p53和Bcl-2）的表达，以确定每种蛋白的表达与肿瘤行为的关系。和患者的预后。在SCC中这些蛋白质之间未发现免疫阳性之间的显着关系。 63例鳞癌中表现出胞质Bax表达（占82.9％）。在异型增生和SCC中，caspase-3阳性病变的凋亡指数均显着高于caspase-3阴性病变的凋亡指数（P = .016，P = .012）。另一方面，不典型增生中凋亡指数（1.18％）与Bax过表达显着相关（P = .006），而在SCC病变中则不相关（P = .129）。通过Kaplan-Meier方法发现Bax阳性SCC患者的预后较差（P = .043）。这些发现表明，在不典型增生中表达的Bax可能起凋亡因子的作用，但是在某些癌性病变中它可能在功能上是失活的，因此在某些人类食管SCC病例中不能抑制肿瘤的进展。

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