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首页> 外文期刊>Modern Pathology >Prognostic relevance of F|[eacute]|d|[eacute]|ration Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases
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Prognostic relevance of F|[eacute]|d|[eacute]|ration Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases

机译：F [[急性] | d | [急性] |定量在去分化脂肪肉瘤中的癌症分级和MDM2扩增水平与预后的相关性：50例研究

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Dedifferentiated liposarcoma represents a form of liposarcoma composed of a non-lipogenic sarcoma associated with well-differentiated liposarcoma. The prognostic significance of histological grading of the dedifferentiated component remains to be elucidated due to vague grading criteria employed in previous studies. Molecular markers of tumor behavior, including amplification levels of murine double minute-2 (MDM2) and cyclin-dependent kinase-4 (CDK4) genes, have been explored in a limited number of cases. Here we investigate whether ‘Fédération Nationale des Centres de Lutte Contre le Cancer’ (FNCLCC) grade and MDM2 gene amplification levels have prognostic value in dedifferentiated liposarcoma in terms of local recurrence and disease-specific survival. Fifty cases were retrieved, reviewed and FNCLCC grade was scored for the dedifferentiated component. Testing for MDM2 gene amplification was performed by fluorescence in situ hybridization. Amplification was categorized as high level (≥20 copies) and as low level (MDM2 amplification on outcomes. Our series includes 50 patients (male n=28, female n=22) with an average age of 63 years (range, 28–88) and a median follow-up of 28 months (range, 2–120). Tumors were graded as grade 1 (6%), grade 2 (58%), and grade 3 (36%). When adjusted for age, sex, site, tumor size, and margin status, grade 3 patients had a higher recurrence rate than grades 1 and 2 (HR=2.07, 95% CI: 1.24, 7.62; P=0.015). Patients with high-level MDM2 amplification had higher recurrence rate on univariate analysis (P=0.028), but not on multivariate analysis (HR=1.69, 95% CI: 0.73, 3.94; P=0.221). FNCLCC grade 3 dedifferentiation confers a worse prognosis in dedifferentiated liposarcoma in terms of local recurrence. MDM2 amplification level remains a useful diagnostic tool in dedifferentiated liposarcoma, but has no prognostic value in terms of local recurrence.
机译：去分化的脂肪肉瘤代表一种形式的脂肪肉瘤，由与高度分化的脂肪肉瘤相关的非脂肪性肉瘤组成。由于先前研究中模糊的分级标准，去分化成分的组织学分级的预后意义尚待阐明。在少数情况下，已经探索了肿瘤行为的分子标志物，包括鼠双分2（MDM2）和细胞周期蛋白依赖性激酶4（CDK4）基因的扩增水平。在这里，我们调查了“国家抗癌中心联合会”（FNCLCC）等级和MDM2基因扩增水平是否在局部未分化脂瘤和特定疾病生存方面具有预后价值。检索，审查了50例病例，并对未分化成分进行了FNCLCC评分。通过荧光原位杂交进行MDM2基因扩增的测试。扩增分为高水平（≥20份）和低水平（MDM2对结果的扩增）。我们的研究包括50例患者（男性n = 28，女性n = 22），平均年龄为63岁（范围28-88） ），平均随访28个月（范围2–120），将肿瘤分为1级（6％），2级（58％）和3级（36％）。年龄，性别，部位，肿瘤大小和边缘状态，3级患者的复发率高于1级和2级（HR = 2.07，95％CI：1.24，7.62; P = 0.015）。 MDM2扩增在单因素分析中具有较高的复发率（P = 0.028），但在多因素分析中则没有（HR = 1.69，95％CI：0.73，3.94; P = 0.221）。FNCLCC 3级去分化赋予去分化脂肪肉瘤的预后更差。在局部复发方面，MDM2扩增水平仍然是去分化脂肪肉瘤的有用诊断工具，但就局部复发而言没有任何预后价值。

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