Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

Kaoru Mitsui; Kanako Ide; Akiko Takayama; Tadahisa Wada; Rie Irie; Ken-ichiro Kosai

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Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

机译：有条件复制的腺病毒通过特异性消除未分化的细胞来防止多能干细胞畸胎瘤

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Incomplete abolition of tumorigenicity creates potential safety concerns in clinical trials of regenerative medicine based on human pluripotent stem cells (hPSCs). Here, we demonstrate that conditionally replicating adenoviruses that specifically target cancers using multiple factors (m-CRAs), originally developed as anticancer drugs, may also be useful as novel antitumorigenic agents in hPSC-based therapy. The survivin promoter was more active in undifferentiated hPSCs than the telomerase reverse transcriptase (TERT) promoter, whereas both promoters were minimally active in differentiated normal cells.

机译：在基于人多能干细胞（hPSC）的再生医学临床试验中，不完全取消致瘤性会带来潜在的安全隐患。在这里，我们证明了使用多种因子（m-CRA）特异性靶向癌症的条件复制腺病毒（最初开发为抗癌药物）也可能在基于hPSC的治疗中用作新型抗肿瘤药。 survivin启动子在未分化的hPSC中比端粒酶逆转录酶（TERT）启动子更具活性，而两个启动子在分化的正常细胞中的活性最低。

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《Molecular Therapy - Methods & Clinical Development》 |2015年第1期|共8页
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Kaoru Mitsui; Kanako Ide; Akiko Takayama; Tadahisa Wada; Rie Irie; Ken-ichiro Kosai;
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中图分类临床医学;
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1. Mesenchymal stem cells deliver and release conditionally replicative adenovirus depending on hepatic differentiation to eliminate hepatocellular carcinoma cells specifically [J] . Yuan Xiangfei, Zhang Qing, Li Zhenzhen, Cancer letters . 2016,第1期

机译：间充质干细胞根据肝细胞的分化来传递和释放条件复制型腺病毒，从而特异性地消除肝细胞癌细胞
2. Derivation of pluripotent stem cells from nascent undifferentiated teratoma (vol 446, pg 43, 2019) [J] . An Yuri, Sekinaka Tamotsu, Tando Yukiko, Developmental biology . 2019,第1期

机译：从新生的未分化畸胎瘤中衍生多能干细胞（Vol 446，PG 43,2019）
3. Derivation of pluripotent stem cells from nascent undifferentiated teratoma [J] . An Yuri, Sekinaka Tamotsu, Tando Yukiko, Developmental biology . 2019,第1期

机译：从新生未分化的畸胎瘤中衍生多能干细胞
4. Automatic identification and delineation of germ layer components in Hon6;E stained images of teratomas derived from human and nonhuman primate embryonic stem cells [C] . Bhagavatula Ramamurthy, Fickus Matthew, Kelly W., IEEE International Symposium on Biomedical Imaging: From Nano to Macro . 2010

机译：Hon6; E染色的人和非人灵长类胚胎干细胞来源的畸胎瘤的细菌层成分的自动鉴定和描绘
5. Mitochondrial and apoptotic dynamics in undifferentiated and differentiating pluripotent stem cells. [D] . Newmark, Judith A. 2009

机译：未分化和分化的多能干细胞的线粒体和凋亡动力学。
6. Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells [O] . Kaoru Mitsui, Kanako Ide, Akiko Takayama, 2015

机译：有条件复制的腺病毒通过特异性消除未分化的细胞来预防多能干细胞畸胎瘤
7. Conditionally replicating adenovirus prevents pluripotent stem cellâderived teratoma by specifically eliminating undifferentiated cells [O] . Kaoru Mitsui, Kanako Ide, Akiko Takayama, 2015

机译：有条件地复制腺病毒通过特异性消除未分化细胞来预防多能干细胞来源的畸胎瘤

Conditionally replicating adenovirus prevents pluripotent stem cell–derived teratoma by specifically eliminating undifferentiated cells

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