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首页> 外文期刊>Molecular vision >Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse
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Dietary zerumbone prevents against ultraviolet B-induced cataractogenesis in the mouse

机译：膳食蛇骨素可预防小鼠中紫外线B引起的白内障

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Purpose: To investigate the preventiveeffect of dietary zerumbone against UVB-induced cataractogenesis. Methods: A total of 50 six-week-oldfemale ICR mice were split into five groups (each contained 10 mice)and exposed to UVB (0.72 J/cm2/daily) at noon for 7 days,except for the blank control group. The mice with UVB exposure were fedwith zerumbone as a dietary supplement at 0, 1, 10, and 100 mg/kg ofbodyweight, respectively, starting from one day before UVB exposure. Onday 7, at 4 h after UVB exposure, all mice were subjected to cataractexamination and lens opacity scoring, in correlation with levels of MDA(malondialdehyde), GSH (glutathione), GR (GSH reductase), GPx(glutathione peroxidase), and SOD (superoxide dismutase) in the lens. Results: Dietary zerumbone at 100 mg/kgafter UVB exposure was effective in decreasing lens opacity scores(p0.001) and to reduce MDA (p0.001), while GSH and GR levelswere significantly increased (both p0.001) in the lens. SOD wasalso increased with dietary zerumbone at 100 mg/kg (p=0.115), whereasGPx (p=0.171) levels were lower as compared with those withoutzerumbone after UVB exposure. Conclusions: These results suggest thatzerumbone may protect against UVB-induced cataractogensis throughreducing lipid peroxides and enhancing the endogenous antioxidant GSHlevel and GR activity.
机译：目的：探讨膳食蛇骨素对UVB诱导的白内障发生的预防作用。方法：将50只六周大的ICR小鼠分为5组（每组10只），并于中午暴露于UVB（0.72 J / cm2 /每天）下7天，空白对照组除外。从暴露于UVB的一天开始，分别以0、1、10和100 mg / kg体重的剂量向饲喂UVB暴露的小鼠饲喂塞鲁骨酮作为膳食补充剂。在第7天的第7天，UVB暴露后，对所有小鼠进行白内障检查和晶状体混浊评分，与MDA（丙二醛），GSH（谷胱甘肽），GR（GSH还原酶），GPx（谷胱甘肽过氧化物酶）和SOD的水平相关（超氧化物歧化酶）在镜头中。结果：暴露于紫外线下的100 mg / kg饮食蛇骨有效降低晶状体混浊度得分（p <0.001）和降低MDA（p <0.001），而GSH和GR水平显着升高（均为p <0.001）。饮食中采骨量为100 mg / kg时，SOD也升高（p = 0.115），而UVB暴露后，GPx（p = 0.171）的水平低于无采骨者。结论：这些结果表明，鱼骨骨可能通过减少脂质过氧化物和增强内源性抗氧化剂GSH水平和GR活性来预防UVB引起的白内障。

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