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首页> 外文期刊>Molecular brain >CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep
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CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep

机译：CaMKIV过度表达促进学习过程中的皮质4-7 Hz振荡和睡眠期间的1-4 Hzδ振荡

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摘要

Mounting evidence suggests that neural oscillations are related to the learning and consolidation of newly formed memory in the mammalian brain. Four to seven Hertz (4-7 Hz) oscillations in the prefrontal cortex are also postulated to be involved in learning and attention processes. Additionally, slow delta oscillations (1-4 Hz) have been proposed to be involved in memory consolidation or even synaptic down scaling during sleep. The molecular mechanisms which link learning-related oscillations during wakefulness to sleep-related oscillations remain unknown. We show that increasing the expression of calcium/calmodulin dependent protein kinase IV (CaMKIV), a key nucleic protein kinase, selectively enhances 4-7.5 Hz oscillation power during trace fear learning and slow delta oscillations during subsequent sleep. These oscillations were found to be boosted in response to the trace fear paradigm and are likely to be localized to regions of the prefrontal cortex. Correlation analyses demonstrate that a proportion of the variance in 4-7.5 Hz oscillations, during fear conditioning, could account for some degree of learning and subsequent memory formation, while changes in slow delta power did not share this predictive strength. Our data emphasize the role of CaMKIV in controlling learning and sleep-related oscillations and suggest that oscillatory activity during wakefulness may be a relevant predictor of subsequent memory consolidation.
机译：越来越多的证据表明，神经振荡与哺乳动物大脑中新形成的记忆的学习和巩固有关。还假设前额叶皮层中有4至7赫兹（4-7 Hz）的振动，与学习和注意力过程有关。另外，已经提出慢增量振动（1-4Hz）与记忆巩固甚至在睡眠期间突触缩小有关。将清醒期间与学习相关的振荡与睡眠相关的振荡联系起来的分子机制仍然未知。我们显示，增加钙/钙调蛋白依赖性蛋白激酶IV（CaMKIV）的表达，一种关键的核酸蛋白激酶，在痕迹恐惧学习过程中选择性增强4-7.5 Hz振荡能力，并在随后的睡眠过程中减慢δ振荡。发现这些振动响应痕量恐惧范式而增强，并且可能局限于额叶前皮层区域。相关分析表明，在恐惧调节过程中，4-7.5 Hz振荡的一部分方差可以解释一定程度的学习和随后的记忆形成，而慢增量功率的变化则没有这种预测强度。我们的数据强调了CaMKIV在控制与学习和睡眠相关的振荡中的作用，并表明在清醒期间的振荡活动可能是后续记忆巩固的相关预测因子。

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