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Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model

机译:自动化的4D树突状脊柱形态分析:在疾病模型中刺激诱发的脊柱重塑和药理学挽救中的应用

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Uncovering the mechanisms that regulate dendritic spine morphology has been limited, in part, by the lack of efficient and unbiased methods for analyzing spines. Here, we describe an automated 3D spine morphometry method and its application to spine remodeling in live neurons and spine abnormalities in a disease model. We anticipate that this approach will advance studies of synapse structure and function in brain development, plasticity, and disease.
机译:揭示调节树突棘形态的机制在一定程度上受到了限制,因为缺乏有效且公正的分析棘突的方法。在这里,我们描述了一种自动3D脊柱形态测量方法及其在活神经元中脊柱重塑和疾病模型中脊柱异常中的应用。我们预期这种方法将促进突触结构和功能在大脑发育,可塑性和疾病中的研究。

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