...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Molecular Cancer >Cancer: tilting at windmills?
【24h】

Cancer: tilting at windmills?

机译：巨蟹座：在风车上倾斜？

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One of the striking characteristics of cancer cells is their phenotypic diversity and ability to switch phenotypes in response to environmental fluctuations. Such phenotypic changes (e.g. from drug-sensitive to drug-resistant), which are critical for survival and proliferation, are widely believed to arise due to mutations in the cancer cell’s genome. However, there is growing concern that such a deterministic view is not entirely consistent with multiple lines of evidence which indicate that cancer can arise in the absence of mutations and can even be reversed to normalcy despite the mutations. In this Commentary, we wish to present an alternate view that highlights how stochasticity in protein interaction networks (PINs) may play a key role in cancer initiation and progression. We highlight the potential role of intrinsically disordered proteins ( IDPs ) and submit that targeting IDPs can lead to new insights and treatment protocols for cancer.
机译：癌细胞的显着特征之一是它们的表型多样性和响应环境波动而转换表型的能力。对于生存和增殖至关重要的这种表型变化（例如，从对药物敏感的变化到对药物耐药的变化）被广泛认为是由于癌细胞基因组的突变而引起的。然而，越来越多的人担心这种确定性观点与多条证据并不完全一致，这些证据表明癌症可以在没有突变的情况下发生，甚至可以在突变的情况下恢复正常。在本评论中，我们希望提出另一种观点，强调蛋白质相互作用网络（PIN）中的随机性如何在癌症的发生和发展中发挥关键作用。我们强调了固有紊乱蛋白（IDP）的潜在作用，并认为靶向IDP可以导致新的见识和癌症治疗方案。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号