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Common strength and localization of spontaneous and evoked synaptic vesicle release sites

机译：自发和诱发突触小泡释放部位的共同强度和定位

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Background Different pools and functions have recently been attributed to spontaneous and evoked vesicle release. Despite the well-established function of evoked release, the neuronal information transmission, the origin as well as the function of spontaneously fusing synaptic vesicles have remained elusive. Recently spontaneous release was found to e.g. regulate postsynaptic protein synthesis or has been linked to depressive disorder. Nevertheless the strength and cellular localization of this release form was neglected so far, which are both essential parameters in neuronal information processing. Findings Here we show that the complete recycling pool can be turned over by spontaneous trafficking and that spontaneous fusion rates critically depend on the neuronal localization of the releasing synapse. Thereby, the distribution equals that of evoked release so that both findings demonstrate a uniform regulation of these fusion modes. Conclusions In contrast to recent works, our results strengthen the assumption that identical vesicles are used for evoked and spontaneous release and extended the knowledge about spontaneous fusion with respect to its amount and cellular localization. Therefore our data supported the hypothesis of a regulatory role of spontaneous release in neuronal outgrowth and plasticity as neurites secrete neurotransmitters to initiate process outgrowth of a possible postsynaptic neuron to form a new synaptic connection.
机译：背景技术近来，不同的池和功能归因于自发的和诱发的囊泡释放。尽管已经确定了诱发释放的功能，但神经元信息传递，自发性以及自发融合突触囊泡的功能仍然难以捉摸。最近发现自发释放例如。调节突触后蛋白的合成或与抑郁症有关。然而，到目前为止，这种释放形式的强度和细胞定位都被忽略了，它们都是神经元信息处理中必不可少的参数。结果在这里，我们显示，完整的回收池可以通过自发贩运来实现，并且自发融合率关键取决于释放突触的神经元定位。因此，分布等于诱发释放的分布，因此两个发现都证明了这些融合模式的统一调节。结论与最近的工作相反，我们的结果加强了假定相同囊泡可用于诱发和自发释放的假设，并扩展了关于自融合的数量和细胞定位方面的知识。因此，我们的数据支持以下假设：自发释放在神经元向外生长和可塑性中起调节作用，因为神经突分泌神经递质以启动可能的突触后神经元的过程向外生长以形成新的突触连接。

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