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HISTOPATHOLOGICAL FEATURES OF RETINOBLASTOMA

机译：视网膜母细胞瘤的组织学特征

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Objective: To study the various histopathological features of retinoblastoma in patients operated in a local teaching hospital.Material and Methods: This prospective, descriptive study was conducted at Eye “A” unit, Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan from 31st December, 2007 to 1st January 2009. Twenty Five children were registered in referral center for retinoblastoma. Based on the results of examination under anesthesia as well as other investigations (CT scan and ultrasonography), a management plan was drawn which also included enucleation in advanced cases. Thirteen patients were included for studies on histopathological features.Results: Out of 13 patients, 8 (61%) were males, 5 (39%) were females ranging in age range from 1 year to 7 years. Mean age was 3.62+1.55 years. Nine (69.2%) cases had unilateral disease. Seven (53.85%) patients had differentiated tumor characterized by Flexner-wintersteiner rosettes, 4 (30.77%) patients had clear optic nerve invasion. Eight (61.54%) specimens revealed necrosis and 5 (38.46%) cases had pigmentation. Four patients with optic nerve invasion and 4 patients with no comments on optic nerve invasion in biopsy report, were offered chemotherapy and local radiotherapy. Rest of 5 patients having no optic nerve invasion, were not given any chemotherapy or radiotherapy after enucleation.Conclusion: Majority of retinobalstoma had well differentiated tumours and about two third having suspician of optic nerve involvement required chemotherapy and radiotherapy. Histopathology report is crucial in devising further treatment plan after surgery.??Key words: Retinoblastoma, Histopathological Features, Optic nerve, Tumour
机译：目的：研究在当地教学医院接受手术的患者视网膜母细胞瘤的各种组织病理学特征。材料与方法：这项前瞻性描述性研究于31日在巴基斯坦白沙瓦开伯尔教学医院眼科“眼科” A部进行。 2007年12月至2009年1月1日。25名儿童在视网膜母细胞瘤转诊中心登记。根据麻醉下的检查结果以及其他检查（CT扫描和超声检查），制定了管理计划，其中还包括晚期病例的摘除术。结果：13例患者中包括13例患者。结果：13例患者中，男性为8例（61％），女性为5例（39％），年龄在1岁至7岁之间。平均年龄为3.62 + 1.55岁。 9例（69.2％）患有单侧疾病。 7例（53.85％）患者已分化为以Flexner-wintersteiner玫瑰花结为特征的肿瘤，4例（30.77％）患者有明显的视神经侵犯。 8例（61.54％）标本显示坏死，5例（38.46％）有色素沉着。活检报告中有4例视神经浸润患者和4例未对视神经浸润发表评论的患者接受了化学疗法和局部放疗。其余5例无视神经浸润的患者，摘除后未接受任何化学疗法或放射疗法。结论：大多数视网膜色素上皮瘤分化良好，约三分之二的怀疑视神经受累的患者需要化学疗法和放射疗法。组织病理学报告对于制定术后的进一步治疗方案至关重要。关键词：视网膜母细胞瘤，组织病理学特征，视神经，肿瘤

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