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首页> 外文期刊>Korean journal of radiology : >In-vivo Visualization of Iron Oxide Enhancement in Focal Pulmonary Inflammatory Lesions Using a Three-Dimensional Radial Gradient-Echo-Based Ultrashort Echo Time Sequence: A Preliminary Study
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In-vivo Visualization of Iron Oxide Enhancement in Focal Pulmonary Inflammatory Lesions Using a Three-Dimensional Radial Gradient-Echo-Based Ultrashort Echo Time Sequence: A Preliminary Study

机译：基于三维径向梯度回波的超短回波时间序列的局灶性肺炎性病变中氧化铁增强的体内可视化：初步研究

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Objective To preliminarily evaluate technical feasibility of a dual-echo ultrashort echo time (UTE) subtraction MR imaging by using concurrent dephasing and excitation (CODE) sequence for visualization of iron-oxide enhancement in focal inflammatory pulmonary lesions. Materials and Methods A UTE pulmonary MR imaging before and after the injection of clinically usable superparamagnetic iron-oxide nanoparticles, ferumoxytol, was conducted using CODE sequence with dual echo times of 0.14 ms for the first echo and 4.15 ms for the second echo on 3T scanner in two rabbits concurrently having granulomatous lung disease and lung cancer in separate lobes. A mean ratio of standardized signal intensity (SI) was calculated for comparison of granulomatous lesion and cancer at first echo, second echo, and subtracted images. Lesions were pathologically evaluated with Prussian blue and immunohistochemistry staining. Results Post-contrast subtracted CODE images visualized exclusive enhancement of iron oxide in granulomatous disease, but not in the cancer (mean ratio of SI, 2.15 ± 0.68 for granulomatous lesion versus 1.00 ± 0.07 for cancer; p value = 0.002). Prussian blue and corresponding anti-rabbit macrophage IgG-staining suggested an intracellular uptake of iron-oxide nanoparticles in macrophages of granulomatous lesions. Conclusion Dual-echo UTE subtraction MR imaging using CODE sequence depicts an exclusive positive enhancement of iron-oxide nanoparticle in rabbits in focal granulomatous inflammatory lesions.
机译：目的通过并发相移和激发（CODE）序列可视化局灶性炎性肺部病变中铁氧化物的增强，初步评估双回波超短回波时间（UTE）减法MR成像的技术可行性。材料和方法使用CODE序列在3T扫描仪上对双回波时间分别为0.14 ms和4.15 ms的双回波时间进行了临床上可注射的超顺磁性氧化铁纳米粒子阿魏酸注射前后的UTE肺MR成像。两只兔子同时患有肉芽肿性肺病和肺癌。计算标准化信号强度（SI）的平均比率，以比较第一次回波，第二次回波和减去图像时肉芽肿病变和癌症。用普鲁士蓝和免疫组织化学染色对病变进行病理学评估。结果造影剂相减后的CODE图像显示肉芽肿病中铁的排他性增强，而癌肿中则无（铁的平均比率，肉芽肿病灶的平均比率为2.15±0.68，癌症为1.00±0.07; p值= 0.002）。普鲁士蓝和相应的抗兔巨噬细胞IgG染色表明肉芽肿性病变巨噬细胞内摄取了氧化铁纳米颗粒。结论使用CODE序列进行双回声UTE减法MR成像可显示兔局灶性肉芽肿性炎性病变中铁纳米颗粒的排他性正增强。

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