Comparison of Effects of Magnesium Sulphate V/S Clonidine as an Adjuvant to Epidural Bupivacaine in Lower Abdominal and Lower Limb Surgeries

Bhumika A Munshi; Ankit Munshi

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Comparison of Effects of Magnesium Sulphate V/S Clonidine as an Adjuvant to Epidural Bupivacaine in Lower Abdominal and Lower Limb Surgeries

机译：硫酸镁V / S可乐定作为硬膜外布比卡因佐剂在下腹部和下肢手术中的作用比较

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Introduction: A prospective, randomized, controlled clinical trial was carried out to evaluate the effects of Magnesium sulphate as an adjuvant to epidural bupivacaine and compared with clonidine along with epidural bupivacaine. Aims and Objective: Main objective to evaluate the efficacy of epidural magnesium sulphate & clonidine used as an adjuvant to bupivacaine. Material and method: After approval from institutional ethical committee 90 patients undergoing lower abdominal &lower limb surgeries selected and devided in 3 groups Control group, magnesium group and clonidine group and different parameters observed. Observation: Co-administration of inj. Magnesium sulphate 50 mg. or Clonidine 3μg/kg (150μg maximum) to epidural bupivacaine produced predictable rapid onset of surgical anaesthesia without significant side effects. Addition of clonidine to epidural bupivacaine produced prolonged duration of analgesia with mild sedation compared to magnesium sulphate. Conclusion: From the study it is suggested that magnesium sulphate can be a useful alternative as an adjuvant to epidural bupivacaine without any side effects.

机译：简介：进行了一项前瞻性，随机对照临床试验，以评估硫酸镁作为硬膜外布比卡因佐剂的作用，并与可乐定和硬膜外布比卡因进行了比较。目的和目的：主要目的是评估硬膜外硫酸镁和可乐定作为布比卡因佐剂的疗效。材料和方法：经机构伦理委员会批准，对90例下腹部和下肢手术患者进行选择并分为3组，对照组，镁组和可乐定组，观察不同的参数。观察：注射用药的共同用药。硫酸镁50毫克。硬膜外注射布比卡因或可乐定3μg/ kg（最大150μg）可产生可预测的手术麻醉快速发作，且无明显副作用。与硫酸镁相比，向硬膜外布比卡因中添加可乐定可延长镇痛时间，并具有轻度镇静作用。结论：从研究中可以看出，硫酸镁可以作为硬膜外布比卡因的佐剂，没有任何副作用。

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《National Journal of Medical Research》 |2016年第3期|共4页
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Bhumika A Munshi; Ankit Munshi;
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1. Comparison of intrathecal clonidine and magnesium sulphate used as an adjuvant with hyperbaric bupivacaine in lower abdominal surgery [J] . Mamta Khandelwal, Debojyoti Dutta, Usha Bafna, Indian journal of Anaesthesia . 2017,第8期

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2. Comparison of dexmedetomidine and clonidine as an adjuvant to ropivacaine for epidural anesthesia in lower abdominal and lower limb surgeries [J] . Sruthi Arunkumar, V.R Hemanth Kumar, N. Krishnaveni, Saudi Journal of Anaesthesia . 2015,第4期

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3. Comparison of Lumbar epidural block using 0.5% Bupivacaine with Butorphanol and 0.5% Bupivacaine with Fentanyl for lower abdominal and lower limb surgeries at SMCH, Ghaziabad, U.P. [J] . Dr. Deepak Mehrotra, Dr. Nitin, Dr. Ashok Kumar, Indian medical journal . 2019,第10期

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4. EMG analysis of lower limb muscle responses to epidural lumbar cord stimulation [C] . Rattay, F., Minassian, Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE . 2003

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5. In vivo quantification of hemodynamic conditions in the human abdominal aorta at rest during lower limb exercise: Research and clinical applications. [D] . Cheng, Christopher Paochung. 2003

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6. Comparison of fentanyl versus meperidine as supplements to epidural clonidine-bupivacaine in patients with lower limb orthopedic surgery under combined spinal epidural anesthesia [O] . Ayman Abd Al-maksoud Yousef, Ashraf Mohamed Atef, Waleed Mohamed Awais 2015

机译：联合硬膜外麻醉在下肢骨科手术患者中使用芬太尼与哌替啶作为硬膜外可乐定布比卡因补充剂的比较
7. Comparison of intrathecal clonidine and magnesium sulphate used as an adjuvant with hyperbaric bupivacaine in lower abdominal surgery [O] . Mamta Khandelwal, Debojyoti Dutta, Usha Bafna, 2017

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Comparison of Effects of Magnesium Sulphate V/S Clonidine as an Adjuvant to Epidural Bupivacaine in Lower Abdominal and Lower Limb Surgeries

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