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首页> 外文期刊>Molecular imaging >The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model
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The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model

机译：生理学和方法学因素对双转基因阿尔茨海默病模型中 18 F-FDG小鼠脑成像的影响

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Introduction: In this study, the influence of physiological determinants on 18F-fluoro- d -glucose (~(18)F-FDG) brain uptake was evaluated in a mouse model of Alzheimer disease. Materials and Methods: TASTPM (Tg) and age-matched C57BL/6 J (WT) mice were fasted for 10 hours, while another group was fasted for 20 hours to evaluate the effect of fasting duration. The effect of repeatedly scanning was evaluated by scanning Tg and WT mice at days 1, 4, and 7. Brain~(18)F-FDG uptake was evaluated in the thalamus being the most indicative region. Finally, the cerebellum was tested as a reference region for the relative standard uptake value (rSUV). Results: When correcting the brain uptake for glucose, the effect of different fasting durations was attenuated and the anticipated hypometabolism in Tg mice was demonstrated. Also, with repeated scanning, the brain uptake values within a group and the hypometabolism of the Tg mice only remained stable over time when glucose correction was applied. Finally, hypometabolism was also observed in the cerebellum, yielding artificially higher rSUV values for Tg mice. Conclusion: Corrections for blood glucose levels have to be applied when semiquantifying~(18)F-FDG brain uptake in mouse models for AD. Potential reference regions for normalization should be thoroughly investigated to ensure that they are not pathologically affected also by afferent connections.
机译：简介：在这项研究中，在阿尔茨海默病小鼠模型中评估了生理决定因素对18F-氟-d-葡萄糖（〜（18）F-FDG）脑摄取的影响。材料和方法：将TASTPM（Tg）和与年龄匹配的C57BL / 6 J（WT）小鼠禁食10小时，而另一组禁食20小时以评估禁食持续时间的影响。通过在第1、4和7天扫描Tg和WT小鼠来评估重复扫描的效果。在丘脑中最具指示性的区域评估了脑（18）F-FDG的摄取。最后，将小脑作为相对标准摄取值（rSUV）的参考区域进行测试。结果：校正大脑对葡萄糖的摄取时，不同禁食时间的作用减弱，并证明了Tg小鼠预期的低代谢。同样，通过重复扫描，当应用葡萄糖校正时，一组内的脑摄取值和Tg小鼠的低代谢仅随时间保持稳定。最后，在小脑中也观察到了代谢不足，从而使Tg小鼠的rSUV值升高。结论：在AD小鼠模型中半定量〜（18）F-FDG脑摄取时，必须校正血糖水平。应该彻底研究潜在的标准化参比区域，以确保它们也不受传入连接的病理影响。

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