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首页> 外文期刊>Nanoscale Research Letters >Fabrication, Characterization and Cytotoxicity of Spherical-Shaped Conjugated Gold-Cockle Shell Derived Calcium Carbonate Nanoparticles for Biomedical Applications
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Fabrication, Characterization and Cytotoxicity of Spherical-Shaped Conjugated Gold-Cockle Shell Derived Calcium Carbonate Nanoparticles for Biomedical Applications

机译：生物医学应用的球形共轭金鸟蛤壳碳酸钙纳米粒子的制备，表征和细胞毒性

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The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO~(3)NPs) for biomedical application. The synthetic technique employed used gold nanoparticle citrate reduction method and a simple precipitation method coupled with mechanical use of a Programmable roller-ball mill. The synthesized conjugated nanomaterial was characterized for its physicochemical properties using transmission electron microscope (TEM), field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR). However, the intricacy of cellular mechanisms can prove challenging for nanomaterial like Au-CSCaCO~(3)NPs and thus, the need for cytotoxicity assessment. The obtained spherical-shaped nanoparticles (light-green purplish) have an average diameter size of 35?±?16?nm, high carbon and oxygen composition. The conjugated nanomaterial, also possesses a unique spectra for aragonite polymorph and carboxylic bond significantly supporting interactions between conjugated nanoparticles. The negative surface charge and spectra absorbance highlighted their stability. The resultant spherical shaped conjugated Au-CSCaCO~(3)NPs could be a great nanomaterial for biomedical applications.
机译：科学中纳米材料的发展带来了纳米技术，生物医学和工程领域的增长。这项研究的目的是用于生物医学应用的共轭金鸟壳壳碳酸钙纳米粒子（Au-CSCaCO〜（3）NPs）的制备和表征。合成技术采用了柠檬酸金纳米颗粒还原法和简单的沉淀法，并结合了可编程滚珠磨机的机械使用。使用透射电子显微镜（TEM），配备能量色散X射线（EDX）的场发射扫描电子显微镜（FESEM）和傅里叶变换红外光谱（FTIR）对合成的共轭纳米材料的理化性质进行了表征。然而，细胞机制的复杂性可能证明对Au-CSCaCO〜（3）NPs等纳米材料具有挑战性，因此需要进行细胞毒性评估。所获得的球形纳米颗粒（浅绿色紫色）的平均直径尺寸为35？±？16？nm，碳和氧的组成较高。共轭纳米材料还具有文石多晶型物和羧基键的独特光谱，显着支持了共轭纳米颗粒之间的相互作用。负表面电荷和光谱吸收值突出了它们的稳定性。所得球形共轭Au-CSCaCO〜（3）NPs可能是生物医学应用的一种很好的纳米材料。

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