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首页> 外文期刊>Nepal Journal of Obstetrics and Gynaecology >Increased Anion Gap Metabolic Acidosis as a Result of 5- Oxoproline (Pyroglutamic Acid) in Pregnancy: A Case Report
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Increased Anion Gap Metabolic Acidosis as a Result of 5- Oxoproline (Pyroglutamic Acid) in Pregnancy: A Case Report

机译：5-羟脯氨酸（焦谷氨酸）在妊娠中导致阴离子间隙代谢性酸中毒增加：一例报告

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Accumulation of 5- Oxoproline (pyroglutamic acid) is a rare cause of severe, high anion gap metabolic acidosis in adults. A 21 year old lady presented at 39 weeks gestation in her first pregnancy with 2 weeks history of shortness of breath. Arterial blood gas showed metabolic acidosis. Urine and serum samples were taken which showed an increase in the serum level of 5- Oxoproline -creatinine ratio indicating pyroglutamic metabolic acidosis. Metabolic acidosis that is caused by 5- oxoproline results from disruption of the gamma glutamyl cycle. Glutamile synthetase (GS) deficiency is an autosomol recessive disorder. With GS deficiency, reduced glutathione levels increases gamma glutamile synthetase activity, and the resulting gamma - glutamile cystine levels are converted to 5-oxoproline.Suspicion for 5-oxoproline-associated high anion gap metabolic acidosis should be made when the cause of high anion gap metabolic acidosis remains poorly defined. DOI: http://www.dx.doi.org/10.3126jog.v7i2.11144 Nepal Journal of Obstetrics and Gynaecology / Vol 7 / No. 2 / Issue 14 / July-Dec, 2012 / 47-49
机译：5-羟脯氨酸（焦谷氨酸）的积累是成年人严重，高阴离子间隙代谢性酸中毒的罕见原因。一位21岁的女士在第一次妊娠时妊娠39周时出现，有2周的呼吸急促史。动脉血气呈代谢性酸中毒。取尿液和血清样品，表明血清5-羟脯氨酸-肌酐比例增加，表明焦谷氨酸代谢性酸中毒。由5-氧代脯氨酸引起的代谢性酸中毒是由γ-谷氨酰胺循环的破坏引起的。谷氨酰胺合成酶（GS）缺乏症是一种常压隐性隐性疾病。由于GS缺乏症，谷胱甘肽水平降低会增加γ谷氨酰胺合成酶的活性，并将由此产生的γ谷氨酰胺胱氨酸水平转化为5-氧代脯氨酸。代谢性酸中毒的定义仍然不明确。 DOI：http://www.dx.doi.org/10.3126jog.v7i2.11144尼泊尔妇产科杂志/第7卷/第2期/第14期/ 2012年7月至12月/ 47-49

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