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首页> 外文期刊>Nepal Journal of Science and Technology >Protective Effects of N. sativa against the Adverse Effects of Aflatoxicosis in Ducklings
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Protective Effects of N. sativa against the Adverse Effects of Aflatoxicosis in Ducklings

机译：苜蓿对小鸭黄曲霉病的不利影响的保护作用

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Aflatoxin produced by Aspergillus flavus toxigenic strain was selected as a potent and widely distributed hepatotoxin that induces much health and economic hazards in animals and humans. A. flavus was cultivated on rice to produce the aflatoxin used in the present study. It was aimed to study the adverse effects of aflatoxin on some biochemical parameters in serum and liver of ducklings as well as to evaluate the possible protective effects of N.sativa crushed seeds against the adverse effects of this. Total proteins, albumin, globulins, alanine aminotransferase (ALT) (EC 2.6.1.1) and aspartate aminotransferase (AST) (EC 2.6.1.2), cholesterol and triacylglycerols were measured in the serum of the test animal. The levels of hepatic malondialdhyde and glutathione level, glutathione S-transferase (GST) (EC: 2.5.1.18) activity, aflatoxin residues and histopathological changes were also measured. The obtained results suggest that the addition of N. sativa to duckling’s ration has a protective effect against aflatoxicosis. The result concluded that aflatoxin had hepatotoxic effects through decrease of total proteins, albumin, glutathione and glutathione S-transferase. In addition, aflatoxin induced histopathological changes of liver of the test animal and residues of aflatoxin were measured. So, we advice to use N. sativa as a feed additive for controlling aflatoxicosis in poultry farm DOI: http://dx.doi.org/10.3126jst.v14i2.10419 Nepal Journal of Science and Technology Vol. 14, No. 2 (2013) 81-90
机译：黄曲霉毒素产毒菌株产生的黄曲霉毒素被选作有效的，广泛分布的肝毒素，在动物和人类中引起很大的健康和经济危害。黄曲霉被种植在水稻上以产生本研究中使用的黄曲霉毒素。目的是研究黄曲霉毒素对雏鸭血清和肝脏中某些生化指标的不利影响，并评估苜蓿粉碎的种子对这种不利影响的可能的保护作用。在测试动物的血清中测量总蛋白，白蛋白，球蛋白，丙氨酸氨基转移酶（ALT）（EC 2.6.1.1）和天冬氨酸氨基转移酶（AST）（EC 2.6.1.2），胆固醇和三酰基甘油。还测量了肝丙二醛和谷胱甘肽水平，谷胱甘肽S-转移酶（GST）（EC：2.5.1.18）活性，黄曲霉毒素残留和组织病理学变化。获得的结果表明，在小鸭的日粮中添加紫花苜蓿对黄曲霉病有保护作用。结果表明，黄曲霉毒素通过减少总蛋白，白蛋白，谷胱甘肽和谷胱甘肽S-转移酶具有肝毒性作用。另外，黄曲霉毒素诱导了试验动物肝脏的组织病理学变化，并测定了黄曲霉毒素的残留量。因此，我们建议在猪场DOI中使用紫花苜蓿作为饲料添加剂来控制黄曲霉病：http://dx.doi.org/10.3126jst.v14i2.10419尼泊尔科学技术学报14（2）（2013）81-90

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