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首页> 外文期刊>Nepal Journal of Science and Technology >Antibiotic Susceptibility Pattern of Bacterial Isolates Causing Wound Infection Among the Patients Visiting B & B Hospital
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Antibiotic Susceptibility Pattern of Bacterial Isolates Causing Wound Infection Among the Patients Visiting B & B Hospital

机译：前往B＆B医院就诊的细菌分离物引起伤口感染的药敏模式

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A wound is any physical injury involving a break in the skin, and exposed subcutaneous tissues provide a favorable substratum for a wide variety of microorganisms to contaminate and colonize. In this study a total of 870 plus samples were collected from patients visiting B & B hospital suspecting wound infection and then analyzed. The causative agents were isolated, identified by culture and biochemical tests and their susceptibility pattern to antibiotics were determined by using CLSI guidelines. Out of total samples, 476(44.8%) showed bacterial growth. Among growth cases 22.9% were mixed growths. Among all bacterial isolates, 12 species were identified of them, 70.6% were Gram-negative and 29.4% were Gram-positive. Among Gram-positive isolates, Staphylococcus. Aureus (74.2%) was most common followed by CoNS (8.6%), Non hemolytic Streptococci (8.6%), Enterococcus spp. (4.3%) and a -haemolytic Streptococci (4.3%). Among Gram-negative bacteria, the most common isolate was Pseudomonas aeruginosa (31.5%) followed by E.coli (24.8%), Acinetobacter spp. (14.6%), Enterobacter spp. (14.0%) and Klebsiella spp. (13.4%). Proteus spp. and Citrobacter spp. were less common. With regard to AST pattern, S. aureus was most susceptible to chloramphenicol and highly resistance to penicillin. Among them, 7.7% were MRSA. For other Gram-positive isolates as well, effective drug was found to be chloramphenicol. For P. aeruginosa , the most effective drug was imipenem (94.3%) followed by amikacin (63.2%). Likewise, for other Gram-negative bacteria most effective drug was imipenem followed by amikacin. Among the total P. aeruginosa isolates, 58.5% were found to be MDR. For all these P. aeruginosa isolates MIC on gentamycin and ciprofloxacin illustrate the simultaneous presence of ciprofloxacin resistance and reduced gentamycin susceptibility. These results indicated that antibiotic resistance in Gram-positive and Gram-negative bacteria were increasing in alarming trend that leads to the failure of treatment. DOI: http://dx.doi.orgjst.v15i2.12121 Nepal Journal of Science and Technology Vol. 15, No.2 (2014) 91-96
机译：伤口是涉及皮肤破裂的任何物理伤害，暴露的皮下组织为各种微生物的污染和定居提供了有利的基质。在这项研究中，从B＆B医院怀疑伤口感染的患者中收集了870多个样本，然后进行了分析。分离病原菌，通过培养和生化测试鉴定，并使用CLSI指南确定其对抗生素的敏感性模式。在总样本中，有476个（44.8％）显示细菌生长。在增长案例中，有22.9％是混合增长。在所有细菌分离物中，鉴定出12种，革兰氏阴性的占70.6％，革兰氏阳性的占29.4％。在革兰氏阳性菌中，葡萄球菌。最常见的是金黄色葡萄球菌（74.2％），其次是CoNS（8.6％），非溶血性链球菌（8.6％），肠球菌。 （4.3％）和溶血性链球菌（4.3％）。在革兰氏阴性菌中，最常见的分离株是铜绿假单胞菌（31.5％），其次是大肠杆菌（24.8％），不动杆菌属。 （14.6％），肠杆菌属。 （14.0％）和克雷伯菌属。 （13.4％）。变形杆菌属和柠檬杆菌属。不太常见。关于AST模式，金黄色葡萄球菌最容易受到氯霉素的影响，并且对青霉素的耐药性很高。其中7.7％为MRSA。对于其他革兰氏阳性分离株，也发现有效药物为氯霉素。对于铜绿假单胞菌，最有效的药物是亚胺培南（94.3％），其次是阿米卡星（63.2％）。同样，对于其他革兰氏阴性细菌，最有效的药物是亚胺培南，其次是丁胺卡那霉素。在总的铜绿假单胞菌分离物中，发现58.5％是MDR。对于所有这些铜绿假单胞菌分离株，庆大霉素和环丙沙星上的MIC均表明同时存在环丙沙星耐药性和庆大霉素敏感性降低。这些结果表明，革兰氏阳性和革兰氏阴性细菌的抗生素耐药性以惊人的趋势增加，导致治疗失败。 DOI：http：//dx.doi.orgjst.v15i2.12121尼泊尔科学技术学报15（2）（2014）91-96

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