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首页> 外文期刊>Nanoscience and Nanoengineering >Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles
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Combination of Sonodynamic and Photodynamic Therapy against Cancer Would Be Effective through Using a Regulated Size of Nanoparticles

机译：通过使用调节大小的纳米粒子，声波和光动力疗法相结合的抗癌疗法将是有效的

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Nanoparticles have been used for many functional materials in nano-sciences and photo-catalyzing surface chemistry. The titanium oxide nanoparticles will be useful for the treatment of tumor by laser and/or ultrasound as the sensitizers in nano-medicine. We have studied the combination therapy of photo- and sono-dynamic therapies in an animal tumor model. Oral-administration of two sensitizers titanium oxide, 0.2%-TiO2 nanoparticles for sono-dynamic and 1 mM 5-aminolevulinic acid for photodynamic therapies have resulted in the best combination therapeutic effects for the cancer treatment. Our light microscopic and Raman spectroscopic studies revealed that the titanium nanoparticles were distributed inside the blood vessel of the cancer tissue (1-3 μm sizes). Among these nanoparticles with a broad size distribution, only particular-sized particles could penetrate through the blood vessel of the cancer tissue, while other particles may only exhibit the side effects in the model mouse. Therefore, it may be necessary to separate the optimum size particles. For this purpose we have separated TiO2 nanoparticles by countercurrent chromatography with a flat coiled column (1.6 mm ID) immersed in an ultrasonic bath (42 KHz). Separation was performed with a two-phase solvent system composed of 1-butanol-acetic acid-water at a volume ratio of 4:1:5 at a flow rate of 0.1 ml/min. Countercurrent chromatographic separation yielded fractions containing particle aggregates at 31 and 4400 nm in diameter.
机译：纳米颗粒已用于纳米科学和光催化表面化学中的许多功能材料。氧化钛纳米颗粒作为纳米药物中的敏化剂，可用于通过激光和/或超声治疗肿瘤。我们已经研究了在动物肿瘤模型中光动力疗法和声动力疗法的组合疗法。两种敏化剂二氧化钛，0.2％-TiO 2 纳米粒子用于声动力疗法和1 mM 5-氨基乙酰丙酸用于光动力疗法的口服给药已产生了最佳的联合治疗效果。我们的光学显微镜和拉曼光谱研究表明，钛纳米颗粒分布在癌组织的血管内（1-3μm大小）。在这些具有宽尺寸分布的纳米颗粒中，只有特定尺寸的颗粒才能穿透癌症组织的血管，而其他颗粒可能仅在模型小鼠中表现出副作用。因此，可能有必要分离最佳尺寸的颗粒。为此，我们通过逆流色谱法将TiO 2 纳米颗粒分离，将扁平螺旋柱（1.6毫米内径）浸入超声浴（42 KHz）中。用体积比为4：1：5的1-丁醇-乙酸-水组成的两相溶剂系统以0.1 ml / min的流速进行分离。逆流色谱分离得到的馏分包含直径为31和4400 nm的颗粒聚集体。

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