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首页> 外文期刊>Kaohsiung Journal of Medical Sciences >Expression of MMP-2, MMP-9 and MMP-11 in dermatofibroma and dermatofibrosarcoma protuberans
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Expression of MMP-2, MMP-9 and MMP-11 in dermatofibroma and dermatofibrosarcoma protuberans

机译：MMP-2，MMP-9和MMP-11在皮肤纤维瘤和隆突性皮肤肉瘤中的表达

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Dermatofibroma (DF) and dermatofibrosarcoma protuberans (DFSP) are the spindle cell mesenchymal neoplasms of the dermis and subcutis. Their histogenesis still remains uncertain and controversial. Traditionally, CD34 and factor XIIIa or other markers have been widely used to distinguish these two diseases. However, the results of these markers reveal overlapping and they lack specificity. Formalin-fixed, paraffin-embedded blocks were collected from the biopsied cases in Kaohsiung Medical University Hospital in Taiwan between 2004 and 2006. This study included 19 cases of DF and 17 cases of DFSP. Immunohistochemical analysis using antibodies CD34, matrix metalloproteinases (MMP)-2, MMP-9, and MMP-11 was performed. We found that the expression of CD34, MMP-2 and MMP-11 shows significant statistical differences in Immunohistochemistry (IHC) study positive or negative reactivity (positive of CD34 in DFSP and positive of MMP-2 and MMP-11 in DF; p =0.03, p <0.001, and p <0.001, respectively) between DF and DFSP. The?result for expression of MMP-9 reveals no differences. The results indicate that the pathogenesis of DF and DFSP are affected by different expressions of extracellular matrix proteins. Metalloproteinases may play a direct role in these two diseases. Since no single marker can completely distinguish DF from DFSP, a combination of more than two or three stains may elevate the accuracy of diagnosis.
机译：真皮纤维瘤（DF）和隆突性皮肤纤维肉瘤（DFSP）是真皮和皮下组织的梭形细胞间质肿瘤。它们的组织发生仍然不确定和有争议。传统上，CD34和XIIIa因子或其他标记已广泛用于区分这两种疾病。但是，这些标记物的结果显示出重叠且缺乏特异性。 2004年至2006年间，从台湾高雄医科大学附属医院的活检病例中收集了福尔马林固定的石蜡包埋块。该研究包括19例DF和17例DFSP。使用抗体CD34，基质金属蛋白酶（MMP）-2，MMP-9和MMP-11进行了免疫组织化学分析。我们发现CD34，MMP-2和MMP-11的表达在免疫组织化学（IHC）研究的阳性或阴性反应性中显示出显着的统计学差异（DFSP中CD34阳性，DF中MMP-2和MMP-11阳性; p = DF和DFSP之间分别为0.03，p <0.001和p <0.001）。 MMP-9表达的结果没有差异。结果表明DF和DFSP的发病机制受细胞外基质蛋白表达的不同影响。金属蛋白酶可能在这两种疾病中起直接作用。由于没有单一的标记物可以完全区分DF和DFSP，因此将两种或三种以上的污渍组合使用可以提高诊断的准确性。

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