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首页> 外文期刊>Nepal Journal of Science and Technology >Beta Lactamase Producing Escherichia coli, Klebsiella pneumoniae and Methicillin Resistant Staphylococcus aureus among Uropathogens
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Beta Lactamase Producing Escherichia coli, Klebsiella pneumoniae and Methicillin Resistant Staphylococcus aureus among Uropathogens

机译：Beta内酰胺酶生产大肠杆菌，肺炎克雷伯菌和耐甲氧西林金黄色葡萄球菌的致病菌

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Urinary tract infection (UTI) is the leading cause of morbidity and health care expenditures in persons of all the ages. The impact of disease is high in the low-resource developing countries due to lack of awareness about the UTIs caused by extended spectrum beta lactamase producing pathogens and methicillin resistant Staphylococcus aureus . This study represents a cross-sectional analysis of UTI prevalence in patients attending at KIST Medical College Teaching Hospital, Imadole, Lalitpur. Bacterial isolates were identified using standard biochemical tests. The antimicrobial susceptibility to various drugs and confirmation of the extended spectrum ?-lactamase (ESBL) and methicillin resistant Staphylococcus aureus (MRSA) production was done following Clinical & Laboratory Standards Institute (CLSI) guidelines. During the study period, 303 (24.08% of urine submissions) UTIs were confirmed. Among these 303 strains, E. coli was the most common, representing 65.34% of the isolates, followed by S. aureus (6.93%) and other pathogens (27.72%). Prevalence of ESBL E. coli, K. pneumoniae and MRSA in the urinary isolates were found to be 38.38 %, 35 % and 47.61 % respectively. Empiric treatment for UTIs in Nepal should be reconsidered and prudent use of antibiotics, particularly Gentamycin, is highly recommended. The recent spread of ESBL-producing Enterobacteriaceae and MRSA is striking and underlines the need for further studies. Nepal Journal of Science and Technology Vol. 16, No.1 (2015) pp. 105-112
机译：泌尿道感染（UTI）是所有年龄段人群发病和医疗保健支出的主要原因。由于缺乏广谱的产生β-内酰胺酶的病原体和耐甲氧西林的金黄色葡萄球菌引起的对UTI的认识不足，该疾病在资源贫乏的发展中国家影响很大。这项研究代表了在Lalitpur的Imadole的KIST医学院教学医院就诊的患者中UTI患病率的横断面分析。使用标准的生化测试鉴定细菌分离株。按照临床和实验室标准协会（CLSI）的指导方针，对各种药物具有抗菌敏感性，并证实了广谱β-内酰胺酶（ESBL）和耐甲氧西林的金黄色葡萄球菌（MRSA）的产生。在研究期间，确认了303个（占尿液提交量的24.08％）UTI。在这303个菌株中，大肠杆菌是最常见的，占分离株的65.34％，其次是金黄色葡萄球菌（6.93％）和其他病原体（27.72％）。发现ESBL大肠杆菌，肺炎克雷伯氏菌和MRSA在尿液分离物中的发生率分别为38.38％，35％和47.61％。应该考虑对尼泊尔的尿路感染进行经验性治疗，强烈建议谨慎使用抗生素，尤其是庆大霉素。产生ESBL的肠杆菌科细菌和MRSA的近期流行令人震惊，并强调了进一步研究的必要性。尼泊尔科学技术学报16（1）（2015）pp.105-112

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