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首页> 外文期刊>Neural regeneration research >N-methyl-D-aspartate receptor subunit 1 regulates neurogenesis in the hippocampal dentate gyrus of schizophrenia-like mice
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N-methyl-D-aspartate receptor subunit 1 regulates neurogenesis in the hippocampal dentate gyrus of schizophrenia-like mice

机译：N-甲基-D-天冬氨酸受体亚基1调节精神分裂症样小鼠海马齿状回的神经发生。

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N-methyl-D-aspartate receptor hypofunction is the basis of pathophysiology in schizophrenia. Blocking the N-methyl-D-aspartate receptor impairs learning and memory abilities and induces pathological changes in the brain. Previous studies have paid little attention to the role of the N-methyl-D-aspartate receptor subunit 1 (NR1) in neurogenesis in the hippocampus of schizophrenia. A mouse model of schizophrenia was established by intraperitoneal injection of 0.6 mg/kg MK-801, once a day, for 14 days. In N-methyl-D-aspartate-treated mice, N-methyl-D-aspartate was administered by intracerebroventricular injection in schizophrenia mice on day 15. The number of NR1-, Ki67- or BrdU-immunoreactive cells in the dentate gyrus was measured by immunofluorescence staining. Our data showed the number of NR1-immunoreactive cells increased along with the decreasing numbers of BrdU- and Ki67-immunoreactive cells in the schizophrenia groups compared with the control group. N-methyl-D-aspartate could reverse the above changes. These results indicated that NR1 can regulate neurogenesis in the hippocampal dentate gyrus of schizophrenia mice, supporting NR1 as a promising therapeutic target in the treatment of schizophrenia. This study was approved by the Experimental Animal Ethics Committee of the Ningxia Medical University, China (approval No. 2014-014) on March 6, 2014.
机译：N-甲基-D-天冬氨酸受体功能减退是精神分裂症病理生理学的基础。阻断N-甲基-D-天冬氨酸受体会损害学习和记忆能力，并诱发大脑的病理变化。以前的研究很少关注精神分裂症海马中N-甲基-D-天冬氨酸受体亚基1（NR1）在神经发生中的作用。通过每天一次腹膜内注射0.6mg / kg MK-801，建立14天的精神分裂症小鼠模型。在用N-甲基-D-天门冬氨酸处理的小鼠中，在第15天通过脑室内注射精神分裂症小鼠施用N-甲基-D-天冬氨酸。测量了齿状回中的NR1，Ki67或BrdU免疫反应性细胞的数量。通过免疫荧光染色。我们的数据显示，与对照组相比，精神分裂症组的NR1免疫反应性细胞数量增加，而BrdU和Ki67免疫反应性细胞数量减少。 N-甲基-D-天冬氨酸可以逆转上述变化。这些结果表明NR1可以调节精神分裂症小鼠海马齿状回中的神经发生，支持NR1作为精神分裂症治疗中有希望的治疗靶标。该研究于2014年3月6日获得中国宁夏医科大学实验动物伦理委员会批准（批准号2014-014）。

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