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首页> 外文期刊>Neural regeneration research >Propofol combined with bone marrow mesenchymal stem cell transplantation improves electrophysiological function in the hindlimb of rats with spinal cord injury better than monotherapy
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Propofol combined with bone marrow mesenchymal stem cell transplantation improves electrophysiological function in the hindlimb of rats with spinal cord injury better than monotherapy

机译：丙泊酚联合骨髓间充质干细胞移植改善脊髓损伤大鼠后肢的电生理功能优于单一疗法

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摘要

The repair effects of bone marrow mesenchymal stem cell transplantation on nervous system damage are not satisfactory. Propofol has been shown to protect against spinal cord injury. Therefore, this study sought to explore the therapeutic effects of their combination on spinal cord injury. Rat models of spinal cord injury were established using the weight drop method. Rats were subjected to bone marrow mesenchymal stem cell transplantation via tail vein injection and/or propofol injection via tail vein using an infusion pump. Four weeks after cell transplantation and/or propofol treatment, the cavity within the spinal cord was reduced. The numbers of PKH-26-positive cells and horseradish peroxidase-positive nerve fibers apparently increased in the spinal cord. Latencies of somatosensory evoked potentials and motor evoked potentials in the hindlimb were noticeably shortened, amplitude was increased and hindlimb motor function was obviously improved. Moreover, the combined effects were better than cell transplantation or propofol injection alone. The above data suggest that the combination of propofol injection and bone marrow mesenchymal stem cell transplantation can effectively improve hindlimb electrophysiological function, promote the recovery of motor funtion, and play a neuroprotective role in spinal cord injury in rats.
机译：骨髓间充质干细胞移植对神经系统损伤的修复效果不理想。异丙酚已被证明可以防止脊髓损伤。因此，本研究试图探索其组合对脊髓损伤的治疗作用。使用失重法建立了脊髓损伤的大鼠模型。使用输液泵通过尾静脉注射和/或通过尾静脉注射异丙酚对大鼠进行骨髓间充质干细胞移植。细胞移植和/或丙泊酚治疗后四个星期，脊髓内的腔减少了。脊髓中PKH-26阳性细胞和辣根过氧化物酶阳性神经纤维的数量明显增加。后肢体感诱发电位和运动诱发电位的潜伏期明显缩短，振幅增加，后肢运动功能明显改善。而且，综合效果优于单独的细胞移植或丙泊酚注射。上述数据表明，异丙酚注射液与骨髓间充质干细胞移植的结合可以有效改善后肢的电生理功能，促进运动功能的恢复，并在大鼠脊髓损伤中发挥神经保护作用。

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