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首页> 外文期刊>Neuropsychopharmacology >Loudness Dependence of Auditory Evoked Potentials as Indicator of Central Serotonergic Neurotransmission: Simultaneous Electrophysiological Recordings and In Vivo Microdialysis in the Rat Primary Auditory Cortex
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Loudness Dependence of Auditory Evoked Potentials as Indicator of Central Serotonergic Neurotransmission: Simultaneous Electrophysiological Recordings and In Vivo Microdialysis in the Rat Primary Auditory Cortex

机译：听觉诱发电位的响度依赖性作为中央血清素神经传递的指标：在大鼠原发性听觉皮层中同时电生理记录和体内微透析。

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Serotonin released in synapsis is one of the key neurotransmitters in psychiatry and psychopharmacology. The loudness dependence of auditory evoked potentials (LDAEP) has been proposed as a marker for central serotonergic neurotransmission. Several findings in animals and humans support this hypothesis. However, the in vivo measurement of cortical extracellular serotonin levels has never been performed simultaneously with the recording of auditory evoked potentials. The interrelationship between low cortical serotonergic activity and strong LDAEP is yet to be proven. The auditory evoked potentials were recorded in the epidura above the primary auditory cortex of male Wistar rats whereas extracellular serotonin levels in the primary auditory cortex were measured by in vivo microdialysis before and after i.p. application of the selective serotonin reuptake inhibitor citalopram. At baseline, the correlation of coefficients between the LDAEP, especially of the N1 component, and extracellular serotonin levels in the primary auditory cortex was negative. The increase of serotonin levels after citalopram application was significantly related to a decrease of LDAEP of the N1 component (r=?0.86, p=0.003). These data support the view that the LDAEP is closely modulated by cortical serotonergic activity. Thus, the LDAEP might serve as an inversely related marker of synaptically released serotonin in the CNS.
机译：突触释放的5-羟色胺是精神病学和心理药理学中的关键神经递质之一。听觉诱发电位（LDAEP）的响度依赖性已被提出作为中央血清素能神经传递的标志。在动物和人类中的一些发现支持这一假设。然而，从未与记录听觉诱发电位同时进行体内皮质细胞外血清素水平的体内测量。低皮质血清素能活性与强LDAEP之间的相互关系尚待证实。听觉诱发电位记录在雄性Wistar大鼠主听皮层上方的硬膜上，而在i.p.之前和之后，通过体内微透析测量了主听皮层中的细胞外血清素水平。血清素再摄取抑制剂西酞普兰的应用在基线时，LDAEP（尤其是N1成分）与初级听觉皮层中细胞外血清素水平之间的系数相关性为负。施用西酞普兰后血清素水平的升高与N1组分LDAEP的降低显着相关（r =？0.86，p = 0.003）。这些数据支持以下观点：LDAEP被皮质血清素能活性密切调节。因此，LDAEP可能是中枢神经系统中突触释放的5-羟色胺的逆相关标记。

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