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首页> 外文期刊>Neuropsychopharmacology >Melatonin Treatment of Winter Depression Following Total Sleep Deprivation: Waking EEG and Mood Correlates
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Melatonin Treatment of Winter Depression Following Total Sleep Deprivation: Waking EEG and Mood Correlates

机译：褪黑素治疗完全睡眠剥夺后的冬季抑郁症：醒来的脑电图和情绪相关

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Patients with winter depression (seasonal affective disorder (SAD)) commonly complain of sleepiness. Sleepiness can be objectively measured by spectral analysis of the waking electroencephalogram (EEG) in the 1–10Hz band. The waking EEG was measured every 3h in 16 female SAD patients and 13 age-matched control women throughout a total sleep deprivation of 30h. Melatonin (or placebo) under double-blind conditions was administered subsequently (0.5mg at 1700h for 6 days), appropriately timed to phase advance circadian rhythms, followed by reassessment in the laboratory for 12h. The increase in EEG power density in a narrow theta band (5–5.99Hz, derivation Fz–Cz) during the 30h protocol was significantly attenuated in patients compared with controls (difference between linear trends p=0.037). Sleepiness (p=0.092) and energy (p=0.045) self-ratings followed a similar pattern. Six patients improved after sleep deprivation (50% reduction on SIGH-SAD22 score). EEG power density dynamics was correlated with clinical response to sleep deprivation: the steeper the build-up (as in controls), the better the improvement (p<0.05). There was no differential effect of melatonin or placebo on any measure; both treatments stabilized the improvement. Overall, patients with winter depression manifest similar wake EEG characteristics as long sleepers or late chronotype with respect to an insufficient build-up of homeostatic sleep pressure. Sleep deprivation was an effective antidepressant treatment for some patients, but evening melatonin was not more efficacious than placebo in sustaining this antidepressant effect.
机译：患有冬季抑郁症（季节性情感障碍（SAD））的患者通常会抱怨嗜睡。嗜睡可以通过对1-10Hz频段的醒脑电图（EEG）进行频谱分析来客观地测量。在总共30个小时的睡眠剥夺中，每3小时对16名女性SAD患者和13名年龄匹配的对照女性进行清醒脑电图测量。随后在双盲条件下施用褪黑激素（或安慰剂）（0.5mg，在1700h持续6天），适当定时以逐步推进昼夜节律，然后在实验室中重新评估12h。与对照组相比，患者在30h规程期间在窄theta频带（5-5.99Hz，Fz-Cz推导）中脑电功率密度的增加与对照组相比明显减弱（线性趋势之间的差异p = 0.037）。嗜睡（p = 0.092）和能量（p = 0.045）的自评遵循相似的模式。睡眠剥夺后有6例患者好转（SIGH-SAD22评分降低了50％）。脑电功率密度动力学与睡眠剥夺的临床反应相关：积累越陡（如对照组），改善越好（p <0.05）。褪黑激素或安慰剂在任何方面均无差异。两种治疗均使病情稳定。总体来说，冬季抑郁症患者表现出与长期睡眠者或晚期表型相似的唤醒EEG特征，这是由于体内稳态睡眠压力不足所致。剥夺睡眠对某些患者是一种有效的抗抑郁药治疗方法，但是夜间褪黑激素在维持这种抗抑郁作用方面并不比安慰剂有效。

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