Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation

Nayoung Kim; Young-In Yoon; Hyun Ju Yoo; Eunyoung Tak; Chul-Soo Ahn; Gi-Won Song; Sung-Gyu Lee; Shin Hwang

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Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation

机译：联合检测血清IL-10，IL-17和CXCL10可以预测成人肝移植后的急性排斥反应

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Discovery of non-invasive diagnostic and predictive biomarkers for acute rejection in liver transplant patients would help to ensure the preservation of liver function in the graft, eventually contributing to improved graft and patient survival. We evaluated selected cytokines and chemokines in the sera from liver transplant patients as potential biomarkers for acute rejection, and found that the combined detection of IL-10, IL-17, and CXCL10 at 1-2 weeks post-operation could predict acute rejection following adult liver transplantation with 97% specificity and 94% sensitivity.

机译：在肝移植患者中发现用于急性排斥的非侵入性诊断和预测生物标志物将有助于确保保留移植物中的肝功能，最终有助于改善移植物和患者的存活率。我们评估了肝移植患者血清中选定的细胞因子和趋化因子作为潜在急性排斥反应的生物标志物，发现在术后1-2周联合检测IL-10，IL-17和CXCL10可以预测以下急性排斥反应成人肝移植的特异性为97％，敏感性为94％。

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《Molecules and cells》 |2016年第8期|共6页
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Nayoung Kim; Young-In Yoon; Hyun Ju Yoo; Eunyoung Tak; Chul-Soo Ahn; Gi-Won Song; Sung-Gyu Lee; Shin Hwang;
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1. Study of the relationships between IL-23R, IL-17, IL-21 polymorphisms and serum level of IL-17, IL-21 with acute graft rejection in iranian liver transplant recipients [J] . Karimi Mohammad Hossein, Hejr Sara, Geramizadeh Bita, Immunological Investigations: A Journal of Molecular and Cellular Immunology . 2014,第1a8期

机译：伊朗肝移植受者急性排斥反应与IL-23R，IL-17，IL-21基因多态性与血清IL-17，IL-21水平的关系的研究
2. Should IFN-gamma, IL-17 and IL-2 be considered predictive biomarkers of acute rejection in liver and kidney transplant? Results of a multicentric study [J] . Millan O., Rafael-Valdivia L., San Segundo D., Clinical immunology: The official journal of the Clinical Immunology Society . 2014,第2期

机译：是否应将IFN-γ，IL-17和IL-2视为肝肾移植急性排斥反应的预测生物标志物？多中心研究的结果
3. High serum soluble CD30 does not predict acute rejection in liver transplant patients. [J] . Matinlauri I, Hockerstedt K, Isoniemi H Transplantation Proceedings . 2006,第10期

机译：高血清可溶性CD30不能预测肝移植患者的急性排斥反应。
4. Shear Wave Velocity and Attenuation in 85 Post-Transplant Liver Patients with Acute Cellular Rejection and Comparison with Biopsy Findings [C] . Lvan Z. Nenadic, Luiz Vasconcelos, Rebeca Pereira, IEEE International Ultrasonics Symposium . 2018

机译：85例急性移植排斥反应的肝移植患者的横波速度和衰减及其与活检结果的比较
5. Role of IL-17 and IL-11 in immunopathology of chronic rejection post-lung transplantation. [D] . Al-Kerithy, Mohammed. 2004

机译：IL-17和IL-11在肺移植后慢性排斥反应的免疫病理学中的作用。
6. Combined Detection of Serum IL-10 IL-17 and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation [O] . Nayoung Kim, Young-In Yoon, Hyun Ju Yoo, 2016

机译：联合检测血清IL-10IL-17和CXCL10可以预测成人肝移植后的急性排斥反应
7. Pre-transplant serum CXCL9 and CXCL10 levels fail to predict acute rejection in kidney transplant recipients receiving induction therapy [O] . Shankar Sushma, Heidt Sebastiaan, Muthusamy Anand, 2011

机译：移植前血清CXCL9和CXCL10水平无法预测接受诱导治疗的肾移植受者的急性排斥反应

Combined Detection of Serum IL-10, IL-17, and CXCL10 Predicts Acute Rejection Following Adult Liver Transplantation

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