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首页> 外文期刊>Neuropsychiatric Disease and Treatment >Heart rate variability biofeedback in patients with?alcohol dependence: a randomized controlled study
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Heart rate variability biofeedback in patients with?alcohol dependence: a randomized controlled study

机译：酒精依赖患者的心率变异性生物反馈：一项随机对照研究

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Background and objective: In patients with alcohol dependence, ethyl-toxic damage of vasomotor and cardiac autonomic nerve fibers leads to autonomic imbalance with neurovascular and cardiac dysfunction, the latter resulting in reduced heart rate variability (HRV). Autonomic imbalance is linked to increased craving and cardiovascular mortality. In this study, we sought to assess the effects of HRV biofeedback training on HRV, vasomotor function, craving, and anxiety. Methods: We conducted a randomized controlled study in 48 patients (14 females, ages 25–59 years) undergoing inpatient rehabilitation treatment. In the treatment group, patients (n=24) attended six sessions of HRV biofeedback over 2 weeks in addition to standard rehabilitative care, whereas, in the control group, subjects received standard care only. Psychometric testing for craving (Obsessive Compulsive Drinking Scale), anxiety (Symptom Checklist-90-Revised), HRV assessment using coefficient of variation of R-R intervals (CVNN) analysis, and vasomotor function assessment using laser Doppler flowmetry were performed at baseline, immediately after completion of treatment or control period, and 3 and 6 weeks afterward (follow-ups 1 and 2). Results: Psychometric testing showed decreased craving in the biofeedback group immediately postintervention (OCDS scores: 8.6±7.9 post-biofeedback versus 13.7±11.0 baseline [mean ± standard deviation], P<0.05), whereas craving was unchanged at this time point in the control group. Anxiety was reduced at follow-ups 1 and 2 post-biofeedback, but was unchanged in the control group (P<0.05). Following biofeedback, CVNN tended to be increased (10.3%±2.8% post-biofeedback, 10.1%±3.5% follow-up 1, 10.1%±2.9% follow-up 2 versus 9.7%±3.6% baseline; P=not significant). There was no such trend in the control group. Vasomotor function assessed using the mean duration to 50% vasoconstriction of cutaneous vessels after deep inspiration was improved following biofeedback immediately postintervention and was unchanged in the control group (P<0.05). Conclusion: Our data indicate that HRV biofeedback might be useful to decrease anxiety, increase HRV, and improve vasomotor function in patients with alcohol dependence when complementing standard rehabilitative inpatient care.
机译：背景与目的：在酒精依赖患者中，血管舒缩和心脏自主神经纤维的乙基毒性损害导致神经血管和心脏功能障碍的自主神经失调，后者导致心率变异性（HRV）降低。自主神经失调与渴望和心血管死亡率增加有关。在这项研究中，我们试图评估HRV生物反馈训练对HRV，血管舒缩功能，渴望和焦虑的影响。方法：我们对48名接受住院康复治疗的患者（14名女性，年龄在25-59岁之间）进行了随机对照研究。在治疗组中，除标准的康复治疗外，患者（n = 24）在2周内参加了六次HRV生物反馈治疗，而在对照组中，受试者仅接受了标准治疗。紧接着在基线时进行了心理测量测试（强迫性饮水量表），焦虑（症状清单-90-修订版），使用RR间隔变异系数（CVNN）分析进行的HRV评估以及使用激光多普勒血流仪进行的血管舒缩功能评估。完成治疗或控制期，以及之后的3和6周（随访1和2）。结果：心理测试显示，干预后即刻，生物反馈组的渴望降低（OCDS评分：生物反馈后为8.6±7.9，而基线时为13.7±11.0 [平均值±标准偏差]，P <0.05），而在这一时间点，渴望并未改变。控制组。生物反馈后的随访1和2焦虑有所减轻，而对照组则没有变化（P <0.05）。生物反馈后，CVNN趋于增加（生物反馈后为10.3％±2.8％，随访1为10.1％±3.5％，随访2为10.1％±2.9％，而基线为9.7％±3.6％; P =不显着） 。对照组没有这种趋势。介入后立即进行生物反馈后，使用深部吸气后皮肤血管平均收缩至50％血管收缩的平均持续时间评估的血管舒缩功能得到了改善，而对照组没有变化（P <0.05）。结论：我们的数据表明，在补充标准的住院治疗时，酒精依赖患者的HRV生物反馈可能有助于减轻焦虑，增加HRV并改善血管舒缩功能。

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