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首页> 外文期刊>Neurology India >Histological spectrum of oligodendroglial tumors: Only a subset shows 1p/19q codeletion
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Histological spectrum of oligodendroglial tumors: Only a subset shows 1p/19q codeletion

机译：少突胶质细胞瘤的组织学谱图：只有一个子集显示1p / 19q编码缺失

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Background: Canonical oligodendroglial tumors (ODGs) are characterized genetically by chromosomes 1p/19q codeletion. Aims: This study was essentially aimed at the detection of frequency of 1p/19q codeletion in the different histological spectrum of ODG tumors in a large cohort of Indian patients. Materials and Methods: All the ODG tumors evaluated for 1p/19q by fluorescence in-situ hybridization (FISH) during 2009–2015 were correlated with histology, immunohistochemical expression for p53 protein and clinical features. Results: A total of 676 cases included both pediatric (n = 18) and adult (n = 658) patients. Histologically, 346 pure ODGs [oligodendroglioma (OD) and anaplastic oligodendroglioma (AOD)] and 330 mixed ODGs [oligoastrocytomas (OA), anaplastic oligoastrocytomas (AOA) and glioblastoma with oligodendroglioma component (GBM-O)] were included. 1p/19q co-deletion was noted in 69% (60/87), 55.9% (145/259), 18.2% (18/99), 10.5% (18/172), and in 5.1% (3/59) cases of OD, AOD, OA, AOA, and GBM-O, respectively. In the pediatric age-group, 1p/19q codeletion was seen in 25% (2/8) of pure ODGs and in 10% (1/10) of mixed ODGs. In adults, it was observed in 60% (203/338) cases of pure ODGs and in 11.9% (38/320) cases of mixed ODGs. In adults, pure ODG histology (P = 0.00), frontal location (P = 0.004), calcification [in pure ODGs] (P = 0.03), and lack of p53 protein overexpression (P = 0.00) showed significant statistical correlation with 1p/19q codeletion. Conclusions: This study is unique in being one of the largest on ODGs for 1p/19q co-deletion including both pediatric and adult age groups of Indian patients. The results showed co-deletion in 60% of adult ODGs and 25% of pediatric pure ODGs. This reemphasizes the occurrence of 1p/19q codeletion, even though rare, in the pediatric age group.
机译：背景：规范性少突胶质细胞瘤（ODG）的特征在于染色体1p / 19q密码子缺失。目的：本研究的主要目的是检测大量印度人队列中ODG肿瘤不同组织学频谱中1p / 19q编码的频率。材料和方法：2009-2015年通过荧光原位杂交（FISH）评估的所有ODG肿瘤的1p / 19q均与组织学，p53蛋白的免疫组织化学表达和临床特征相关。结果：总共676例患者包括小儿（n = 18）和成人（n = 658）患者。在组织学上，包括346个纯ODG [少突胶质细胞瘤（OD）和间变性少突胶质细胞瘤（AOD）]和330种混合ODG [少突胶质细胞瘤（OA），间变性少突胶质细胞瘤（AOA）和具有少突胶质细胞瘤成分的胶质母细胞瘤（GBM-O）]。 1p / 19q共删除率分别为69％（60/87），55.9％（145/259），18.2％（18/99），10.5％（18/172）和5.1％（3/59）分别为OD，AOD，OA，AOA和GBM-O。在儿童年龄组中，在25％（2/8）的纯ODG和10％（1/10）的混合ODG中看到了1p / 19q编码缺失。在成人中，有60％（203/338）的纯ODG和11.9％（38/320）的混合ODG出现了这种情况。在成年人中，纯ODG的组织学（P = 0.00），额叶位置（P = 0.004），钙化[在纯ODG中]（P = 0.03）和缺乏p53蛋白的过表达（P = 0.00）与1p /具有显着的统计学相关性。 19q代码删除。结论：这项研究的独特之处在于它是1p / 19q共删除ODG的最大对象之一，包括印度患者的儿科和成年年龄组。结果表明，共删除了60％的成人ODG和25％的儿科纯ODG。这再次强调了在小儿年龄组中1p / 19q代号的发生，尽管很罕见。

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