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首页> 外文期刊>NeuroImage: Clinical >Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis
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Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis

机译：磁共振弹性成像显示实验性自身免疫性脑脊髓炎的脑粘弹性改变

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Cerebral magnetic resonance elastography (MRE) measures the viscoelastic properties of brain tissues in vivo. It was recently shown that brain viscoelasticity is reduced in patients with multiple sclerosis (MS), highlighting the potential of cerebral MRE to detect tissue pathology during neuroinflammation. To further investigate the relationship between inflammation and brain viscoelasticity, we applied MRE to a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). EAE was induced and monitored by MRE in a 7-tesla animal MRI scanner over 4weeks. At the peak of the disease (day 14 after immunization), we detected a significant decrease in both the storage modulus (G′) and the loss modulus (G″), indicating that both the elasticity and the viscosity of the brain are reduced during acute inflammation. Interestingly, these parameters normalized at a later time point (day 28) corresponding to the clinical recovery phase. Consistent with this, we observed a clear correlation between viscoelastic tissue alteration and the magnitude of perivascular T cell infiltration at both day 14 and day 28. Hence, acute neuroinflammation is associated with reduced mechanical cohesion of brain tissues. Moreover, the reduction of brain viscoelasticity appears to be a reversible process, which is restored when inflammation resolves. For the first time, our study has demonstrated the applicability of cerebral MRE in EAE, and showed that this novel imaging technology is highly sensitive to early tissue alterations resulting from the inflammatory processes. Thus, MRE may serve to monitor early stages of perivascular immune infiltration during neuroinflammation.
机译：脑磁共振弹性成像（MRE）可测量体内脑组织的粘弹性。最近显示，多发性硬化症（MS）患者的脑粘弹性降低，突显了脑MRE在神经炎症过程中检测组织病理学的潜力。为了进一步研究炎症与脑粘弹性之间的关系，我们将MRE应用于MS小鼠模型，即实验性自身免疫性脑脊髓炎（EAE）。在4周内，由MRE在7特斯拉动物MRI扫描仪中诱导和监测EAE。在疾病的高峰期（免疫后第14天），我们发现储能模量（G'）和损失模量（G''）均显着下降，这表明在此期间大脑的弹性和黏度均降低了急性炎症。有趣的是，这些参数在对应于临床恢复阶段的稍后时间点（第28天）进行了标准化。与此相一致，我们在第14天和第28天观察到粘弹性组织改变与血管周围T细胞浸润程度之间存在明显的相关性。因此，急性神经炎症与脑组织机械凝聚力降低相关。此外，脑粘弹性的降低似乎是一个可逆的过程，炎症消退后可恢复。我们的研究首次证明了脑MRE在EAE中的适用性，并表明这种新颖的成像技术对炎症过程引起的早期组织改变高度敏感。因此，MRE可用于监测神经炎症期间血管周围免疫浸润的早期阶段。

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