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首页> 外文期刊>NeuroImage: Clinical >Abnormalities in the brain of streptozotocin-induced type 1 diabetic rats revealed by diffusion tensor imaging
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Abnormalities in the brain of streptozotocin-induced type 1 diabetic rats revealed by diffusion tensor imaging

机译：弥散张量成像显示链脲佐菌素诱导的1型糖尿病大鼠脑部异常

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摘要

Diabetes mellitus affects the brain. Both type 1 and type 2 diabetic patients are associated with white matter (WM) damage observable to diffusion tensor imaging (DTI). The underlying histopathological mechanisms, however, are poorly understood. The objectives of this study are 1) to determine whether streptozotocin (STZ)-induced type 1 diabetes is associated with WM damage observable to DTI; and 2) to understand the pathophysiological aspects underlying STZ-induced brain injuries. Male Sprague–Dawley rats received a single intraperitoneal injection of STZ (62mg/kg). DTI was used to assess brain abnormalities at 4weeks after induction, combined with histological assessments and ultrastructural analysis. Compared to controls, the STZ-induced rats showed significantly reduced fractional anisotropy (FA) in the motor/somatosensory cortex and striatum. Histologically, the cortex and striatum of the diabetic animals are characterized by demyelination and axonal degradation. In conclusion, STZ-induced diabetes is associated with striatal/cortical injuries observable to DTI. The DTI abnormalities are likely manifestations of demyelination and axonal degradation in the affected brain regions, and can potentially be used as surrogates for evaluating diabetic brain injuries.
机译：糖尿病会影响大脑。 1型和2型糖尿病患者均与弥散张量成像（DTI）可见的白质（WM）损伤相关。然而，人们对潜在的组织病理学机制了解甚少。这项研究的目的是：1）确定链脲佐菌素（STZ）诱导的1型糖尿病是否与DTI观察到的WM损伤有关;和2）了解STZ诱发的脑损伤的病理生理学方面。 Sprague–Dawley雄性大鼠腹膜内注射STZ（62mg / kg）。 DTI用于在诱导后4周评估脑异常，并结合组织学评估和超微结构分析。与对照组相比，STZ诱导的大鼠在运动/体感皮层和纹状体中的分数各向异性（FA）显着降低。组织学上，糖尿病动物的皮质和纹状体的特征是脱髓鞘和轴突降解。总之，STZ诱发的糖尿病与DTI可观察到的纹状体/皮质损伤有关。 DTI异常可能是受影响的大脑区域脱髓鞘和轴突降解的表现，并且有可能被用作评估糖尿病性脑损伤的替代物。

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