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Scoring by nonlocal image patch estimator for early detection of Alzheimer's disease

机译：通过非局部图像补丁估计器评分，以早期发现阿尔茨海默氏病

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Detection of Alzheimer's disease (AD) at the first stages of the pathology is an important task to accelerate the development of new therapies and improve treatment. Compared to AD detection, the prediction of AD using structural MRI at the mild cognitive impairment (MCI) or pre-MCI stage is more complex because the associated anatomical changes are more subtle. In this study, we analyzed the capability of a recently proposed method, SNIPE (Scoring by Nonlocal Image Patch Estimator), to predict AD by analyzing entorhinal cortex (EC) and hippocampus (HC) scoring over the entire ADNI database (834 scans). Detection (AD vs. CN) and prediction (progressive — pMCI vs. stable — sMCI) efficiency of SNIPE were studied using volumetric and grading biomarkers. First, our results indicate that grading-based biomarkers are more relevant for prediction than volume-based biomarkers. Second, we show that HC-based biomarkers are more important than EC-based biomarkers for prediction. Third, we demonstrate that the results obtained by SNIPE are similar to or better than results obtained in an independent study using HC volume, cortical thickness, and tensor-based morphometry, individually and in combination. Fourth, a comparison of new patch-based methods shows that the nonlocal redundancy strategy involved in SNIPE obtained similar results to a new local sparse-based approach. Finally, we present the first results of patch-based morphometry to illustrate the progression of the pathology.
机译：在病理学的最初阶段检测阿尔茨海默氏病（AD）是加快开发新疗法和改善治疗的一项重要任务。与AD检测相比，在轻度认知障碍（MCI）或MCI之前阶段使用结构MRI对AD的预测更为复杂，因为相关的解剖学变化更加微妙。在这项研究中，我们分析了最近提出的方法SNIPE（通过非局部图像斑块估计器评分）通过分析整个ADNI数据库（834次扫描）的内嗅皮质（EC）和海马（HC）得分来预测AD的能力。使用体积和分级生物标记物研究了SNIPE的检测效率（AD与CN）和预测效率（渐进式-pMCI与稳定-sMCI）。首先，我们的结果表明，基于等级的生物标记比基于体积的生物标记与预测更相关。第二，我们证明，基于HC的生物标记比基于EC的生物标记更重要。第三，我们证明了通过SNIPE获得的结果与单独或组合使用HC体积，皮质厚度和基于张量的形态测量的独立研究获得的结果相似或更好。第四，对新的基于补丁的方法的比较表明，SNIPE中涉及的非本地冗余策略获得了与基于新的基于本地稀疏方法的相似结果。最后，我们介绍基于补丁的形态学的第一个结果，以说明病理学的进展。

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