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首页> 外文期刊>NeuroImage: Clinical >Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury
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Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury

机译：计算分析表明，反复轻度脑外伤后血液沉积增加

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Mild traumatic brain injury (mTBI) has become an increasing public health concern as subsequent injuries can exacerbate existing neuropathology and result in neurological deficits. This study investigated the temporal development of cortical lesions using magnetic resonance imaging (MRI) to assess two mTBIs delivered to opposite cortical hemispheres. The controlled cortical impact model was used to produce an initial mTBI on the right cortex followed by a second injury induced on the left cortex at 3 (rmTBI 3d) or 7 (rmTBI 7d) days later. Histogram analysis was combined with a novel semi-automated computational approach to perform a voxel-wise examination of extravascular blood and edema volumes within the lesion. Examination of lesion volume 1d post last injury revealed increased tissue abnormalities within rmTBI 7d animals compared to other groups, particularly at the site of the second impact. Histogram analysis of lesion T2 values suggested increased edematous tissue within the rmTBI 3d group and elevated blood deposition in the rm TBI 7d animals. Further quantification of lesion composition for blood and edema containing voxels supported our histogram findings, with increased edema at the site of second impact in rmTBI 3d animals and elevated blood deposition in the rmTBI 7d group at the site of the first injury. Histological measurements revealed spatial overlap of regions containing blood deposition and microglial activation within the cortices of all animals. In conclusion, our findings suggest that there is a window of tissue vulnerability where a second distant mTBI, induced 7d after an initial injury, exacerbates tissue abnormalities consistent with hemorrhagic progression. Highlights ? rmTBI 7d apart resulted in an increased total lesion volume 1d post last injury. ? Lesion volume was increased at the distant second injury site in rmTBI 7d animals. ? Increased edema was seen at the distant second injury site in rmTBI 3d animals. ? Voxel-wise analysis detected hemorrhagic progression in rmTBI 7d animals. ? Increased microglia were observed in the rmTBI 7d animals.
机译：轻度创伤性脑损伤（mTBI）已成为公共卫生日益关注的问题，因为随后的损伤会加剧现有的神经病理学并导致神经功能缺损。这项研究使用磁共振成像（MRI）研究了皮质病变的暂时发展，以评估两个传递至相对皮质半球的mTBI。受控的皮质撞击模型用于在3天（rmTBI 3d）或7天（rmTBI 7d）后在右侧皮质产生初始mTBI，然后在左侧皮质诱发第二次损伤。直方图分析与新颖的半自动计算方法相结合，对病灶内的血管外血液和浮肿进行体素检查。在最后一次损伤后第1d进行的病变体积检查显示，与其他组相比，rmTBI 7d动物内部组织异常增加，尤其是在第二次撞击部位。病变T2值的直方图分析表明，rmTBI 3d组的水肿组织增加，而rm TBI 7d动物的血液沉积升高。进一步量化包含血和水肿的体素的病变成分，支持了我们的直方图结果，在rmTBI 3d动物的第二次撞击部位水肿增加，而在rmTBI 7d组在第一次受伤部位血沉增加。组织学测量显示所有动物皮层中包含血液沉积和小胶质细胞活化的区域的空间重叠。总之，我们的发现表明存在组织脆弱性的窗口，在初始损伤后第7天诱发的第二个远距mTBI加剧了与出血进展一致的组织异常。强调 ？ rmTBI相距7d导致上次受伤后1d的总病变体积增加。 ？在rmTBI 7d动物的远处第二损伤部位，病变体积增加。 ？ rmTBI 3d动物在较远的第二次损伤部位发现水肿增加。 ？体素分析检测到rmTBI 7d动物的出血进展。 ？在rmTBI 7d动物中观察到小胶质细胞增加。

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