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首页> 外文期刊>NeuroImage: Clinical >Frontal and superior temporal auditory processing abnormalities in schizophrenia
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Frontal and superior temporal auditory processing abnormalities in schizophrenia

机译：精神分裂症的额叶和颞上听觉处理异常

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Background Although magnetoencephalography (MEG) studies show superior temporal gyrus (STG) auditory processing abnormalities in schizophrenia at 50 and 100ms, EEG and corticography studies suggest involvement of additional brain areas (e.g., frontal areas) during this interval. Study goals were to identify 30 to 130ms auditory encoding processes in schizophrenia (SZ) and healthy controls (HC) and group differences throughout the cortex. Methods The standard paired-click task was administered to 19 SZ and 21 HC subjects during MEG recording. Vector-based Spatial–temporal Analysis using L1-minimum-norm (VESTAL) provided 4D maps of activity from 30 to 130ms. Within-group t-tests compared post-stimulus 50ms and 100ms activity to baseline. Between-group t-tests examined 50 and 100ms group differences. Results Bilateral 50 and 100ms STG activity was observed in both groups. HC had stronger bilateral 50 and 100ms STG activity than SZ. In addition to the STG group difference, non-STG activity was also observed in both groups. For example, whereas HC had stronger left and right inferior frontal gyrus activity than SZ, SZ had stronger right superior frontal gyrus and left supramarginal gyrus activity than HC. Conclusions Less STG activity was observed in SZ than HC, indicating encoding problems in SZ. Yet auditory encoding abnormalities are not specific to STG, as group differences were observed in frontal and SMG areas. Thus, present findings indicate that individuals with SZ show abnormalities in multiple nodes of a concurrently activated auditory network. Highlights ? Auditory encoding in schizophrenia (SZ) and healthy controls (HC) was examined. ? Distributed source localization provided whole-brain measures from 30 to 130ms. ? Abnormalities were observed in superior temporal gyrus (STG) auditory areas in SZ. ? Encoding abnormalities were also observed in frontal and supramarginal gyrus areas. ? SZ shows abnormalities in multiple nodes of a distributed auditory network.
机译：背景技术尽管脑磁图（MEG）研究显示精神分裂症在50和100毫秒时存在上颞回（STG）听觉处理异常，但脑电图和皮层造影研究表明在此间隔内还涉及其他大脑区域（例如额叶区域）。研究目标是确定精神分裂症（SZ）和健康对照（HC）中30到130ms的听觉编码过程以及整个皮层的群体差异。方法在MEG记录过程中，对19名SZ和21名HC受试者执行了标准的配对单击任务。使用L1最小范数（VESTAL）的基于矢量的时空分析提供了30ms至130ms的4D活动图。组内t检验比较了刺激后50ms和100ms活动与基线之间的关系。组间t检验检验了50ms和100ms组差异。结果两组均观察到双边50和100ms STG活性。 HC具有比SZ更强的双边50和100ms STG活性。除了STG组差异外，两组均未观察到非STG活性。例如，虽然HC比SZ具有更强的左，右下额回活动能力，但SZ却比HC具有更强的右上额回和左上臀功能。结论在SZ中观察到的STG活性低于HC，这表明在SZ中存在编码问题。然而，听觉编码异常并非特定于STG，因为在额叶和SMG区域观察到了群体差异。因此，目前的发现表明患有SZ的个体在同时激活的听觉网络的多个节点中显示异常。强调 ？检查了精神分裂症（SZ）和健康对照（HC）的听觉编码。 ？分布式源本地化提供了30到130毫秒的全脑测量。 ？在深圳上颞回（STG）听觉区域观察到异常。 ？在额回和上回中也观察到编码异常。 ？ SZ显示了分布式听觉网络的多个节点中的异常。

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