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首页> 外文期刊>NeuroImage: Clinical >The influence of cerebral small vessel disease on default mode network deactivation in mild cognitive impairment
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The influence of cerebral small vessel disease on default mode network deactivation in mild cognitive impairment

机译：脑小血管疾病对轻度认知障碍中默认模式网络失活的影响

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Introduction Cerebral small vessel disease (CSVD) is thought to contribute to cognitive dysfunction in patients with mild cognitive impairment (MCI). The underlying mechanisms, and more specifically, the effects of CSVD on brain functioning in MCI are incompletely understood. The objective of the present study was to examine the effects of CSVD on brain functioning, activation and deactivation, in patients with MCI using task-related functional MRI (fMRI). Methods We included 16 MCI patients with CSVD, 26 MCI patients without CSVD and 25 controls. All participants underwent a physical and neurological examination, neuropsychological testing, structural MRI, and fMRI during a graded working memory paradigm. Results MCI patients with and without CSVD had a similar neuropsychological profile and task performance during fMRI, but differed with respect to underlying (de)activation patterns. MCI patients with CSVD showed impaired deactivation in the precuneus/posterior cingulate cortex, a region known to be involved in the default mode network. In MCI patients without CSVD, brain activation depended on working memory load, as they showed relative ‘hyperactivation’ during vigilance, and ‘hypoactivation’ at a high working memory load condition in working memory related brain regions. Conclusions We present evidence that the potential underlying mechanism of CSVD affecting cognition in MCI is through network interference. The observed differences in brain activation and deactivation between MCI patients with and without CSVD, who had a similar ‘clinical phenotype’, support the view that, in patients with MCI, different types of pathology can contribute to cognitive impairment through different pathways.
机译：简介脑小血管疾病（CSVD）被认为可导致轻度认知障碍（MCI）患者的认知功能障碍。潜在的机制，更具体地说，CSVD对MCI中脑功能的影响尚不完全清楚。本研究的目的是使用任务相关功能MRI（fMRI）研究CSVD对MCI患者的脑功能，激活和失活的影响。方法我们纳入了16例CSVD的MCI患者，26例无CSVD的MCI患者和25例对照。在分级工作记忆范例中，所有参与者均接受了身体和神经系统检查，神经心理学测试，结构性MRI和fMRI。结果有和没有CSVD的MCI患者在fMRI期间具有相似的神经心理学特征和任务表现，但是在基本（去激活）模式方面有所不同。患有CSVD的MCI患者在前/后扣带皮层（已知参与默认模式网络的区域）显示出失活。在没有CSVD的MCI患者中，大脑激活取决于工作记忆负荷，因为他们在警惕期间表现出相对的“过度激活”，而在工作记忆相关的大脑区域中处于较高的工作记忆负荷条件下则表现为“过度激活”。结论我们提供的证据表明CSVD影响MCI认知的潜在潜在机制是通过网络干扰。在有和没有CSVD的MCI患者之间，观察到的在大脑活动和失活之间的差异都有相似的“临床表型”，这支持以下观点：在MCI患者中，不同类型的病理可能通过不同的途径导致认知障碍。

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