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首页> 外文期刊>NeuroImage: Clinical >Not lesser but Greater fractional anisotropy in adolescents with alcohol use disorders
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Not lesser but Greater fractional anisotropy in adolescents with alcohol use disorders

机译：在酒精滥用障碍青少年中，各向异性程度较小，但较大

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Objective The objective of this study is to examine white matter microstructure using diffusion tensor imaging (DTI) in a sample of adolescents with alcohol use disorders (AUD) and no psychiatric or substance co-morbidity. Methods Fifty adolescents with AUD and fifty non-alcohol abusing controls matched on gender and age were studied with DTI, neurocognitive testing, and a clinical assessment that included measures of alcohol use and childhood trauma. Maps of fractional anisotropy (FA) and mean diffusivity (MD) were computed, registered to a common template, and voxel-wise statistical analysis used to assess group differences. Associations between regions of altered WM microstructure and clinical or neurocognitive measures were also assessed. Results Compared with controls, adolescent drinkers without co-morbid substance abuse or externalizing disorder, showed 1) no regions of significantly lower FA, 2) increased FA in WM tracts of the limbic system; 3) no MD differences; and 4) within the region of higher FA in AUD, there were no associations between FA and alcohol use, cognition, or trauma. Discussion The most important observation of this study is our failure to observe significantly smaller FA in this relatively large alcohol abuse/dependent adolescent sample. Greater FA in the limbic regions observed in this study may index a risk for adolescent AUD instead of a consequence of drinking. Drinking behavior may be reinforced in those with higher FA and perhaps greater myelination in these brain regions involved in reward and reinforcement. Highlights ? Adolescents with alcohol use disorders were studied using diffusion tensor imaging. ? No regions of lower fractional anisotropy in adolescent drinkers vs. controls. ? Limbic system fractional anisotropy was increased in adolescent drinkers. ? No differences in mean diffusivity were observed. ? There were no associations between fractional anisotropy and clinical measures.
机译：目的这项研究的目的是使用扩散张量成像（DTI）在患有酒精使用障碍（AUD）且没有精神病或物质合并症的青少年样本中检查白质微观结构。方法采用DTI，神经认知测试以及包括饮酒和儿童期创伤在内的临床评估方法，对五十名患有AUD的青少年和五十名按性别和年龄相匹配的非酗酒对照进行研究。计算分数各向异性（FA）和平均扩散率（MD）的图，将其映射到通用模板，并使用体素统计分析法评估组差异。还评估了WM微观结构改变的区域与临床或神经认知措施之间的关联。结果与对照组相比，没有共病物质滥用或外在性障碍的青春期饮酒者显示：1）没有边缘区域FA明显降低的区域; 2）边缘系统WM区域FA增加; 3）MD差异无; 4）在澳元中FA较高的区域内，FA与饮酒，认知或创伤之间没有关联。讨论这项研究最重要的观察结果是我们未能在相对较大的酗酒/依赖的青少年样本中观察到显着较小的FA。在这项研究中观察到的边缘区域较大的FA可能表明存在青少年AUD的风险，而不是饮酒的后果。在那些具有奖励和强化作用的大脑区域中，FA较高且髓鞘增多的患者可能会增强饮酒行为。强调 ？使用扩散张量成像研究了患有酒精使用障碍的青少年。 ？与对照组相比，青春期饮酒者没有更低的分数各向异性区域。 ？青少年饮酒者的边缘系统分数各向异性增加。 ？没有观察到平均扩散率的差异。 ？分数各向异性与临床指标之间没有关联。

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