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首页> 外文期刊>NeuroImage: Clinical >Using concurrent EEG and fMRI to probe the state of the brain in schizophrenia
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Using concurrent EEG and fMRI to probe the state of the brain in schizophrenia

机译：使用同时进行的脑电图和功能磁共振成像检查精神分裂症的大脑状态

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Perceptional abnormalities in schizophrenia are associated with hallucinations and delusions, but also with negative symptoms and poor functional outcome. Perception can be studied using EEG-derived event related potentials (ERPs). Because of their excellent temporal resolution, ERPs have been used to ask when perception is affected by schizophrenia. Because of its excellent spatial resolution, functional magnetic resonance imaging (fMRI) has been used to ask where in the brain these effects are seen. We acquired EEG and fMRI data simultaneously to explore when and where auditory perception is affected by schizophrenia. Thirty schizophrenia (SZ) patients and 23 healthy comparison subjects (HC) listened to 1000 Hz tones occurring about every second. We used joint independent components analysis (jICA) to combine EEG-based event-related potential (ERP) and fMRI responses to tones. Five ERP-fMRI joint independent components (JIC) were extracted. The “N100” JIC had temporal weights during N100 (peaking at 100 ms post-tone onset) and fMRI spatial weights in superior and middle temporal gyri (STG/MTG); however, it did not differ between groups. The “P200” JIC had temporal weights during P200 and positive fMRI spatial weights in STG/MTG and frontal areas, and negative spatial weights in the nodes of the default mode network (DMN) and visual cortex. Groups differed on the “P200” JIC: SZ had smaller “P200” JIC, especially those with more severe avolition/apathy. This is consistent with negative symptoms being related to perceptual deficits, and suggests patients with avolition/apathy may allocate too few resources to processing external auditory events and too many to processing internal events. Highlights ? Perceptual deficits in schizophrenia (SZ) were assessed using concurrent EEG + fMRI. ? Joint independent components (JIC) analysis integrated EEG-based ERP and fMRI data. ? “N100” and “P200” JICs were associated with auditory cortical activity. ? “P200” JIC was inversely related to visual and default mode network (DMN) activity. ? SZ had smaller “P200” JICs, especially those with severe negative symptoms.
机译：精神分裂症的知觉异常与幻觉和妄想有关，但也与阴性症状和不良的功能预后有关。可以使用源自脑电图的事件相关电位（ERP）研究知觉。由于其出色的时间分辨率，ERP已被用来询问何时受精神分裂症影响。由于其出色的空间分辨率，功能磁共振成像（fMRI）已被用于询问在大脑中哪些位置可以看到这些效果。我们同时获取了脑电图和功能磁共振成像数据，以探索何时和何地听觉感知受精神分裂症影响。 30位精神分裂症（SZ）患者和23位健康的比较对象（HC）听到了每秒发出的1000 Hz音调。我们使用联合独立成分分析（jICA）结合了基于EEG的事件相关电位（ERP）和功能磁共振成像对音调的反应。提取了五个ERP-fMRI关节独立组件（JIC）。 “ N100” JIC在N100期间（音后发病100毫秒时达到峰值）具有时间权重，而在颞中上回（STG / MTG）具有fMRI空间权重;但是，各组之间没有区别。 “ P200” JIC在P200期间具有时间权重，在STG / MTG和额叶区域的fMRI空间权重为正，而在默认模式网络（DMN）和视觉皮层的节点中空间负权为负。 “ P200” JIC的群体有所不同：SZ的“ P200” JIC较小，尤其是那些具有较严重的意志力/上进心的人。这与与知觉缺陷相关的消极症状是一致的，并且表明患有麻木/麻木的患者可能分配很少的资源来处理外部听觉事件，而分配太多的资源来处理内部事件。强调 ？精神分裂症（SZ）的知觉缺陷使用同步脑电图+功能磁共振成像进行评估。 ？联合独立组件（JIC）分析集成了基于EEG的ERP和fMRI数据。 ？ “ N100”和“ P200” JIC与听觉皮层活动相关。 ？ “ P200” JIC与视觉和默认模式网络（DMN）活动成反比。 ？深圳的P200 JIC较小，尤其是那些具有严重负面症状的JIC。

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