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首页> 外文期刊>NeuroImage: Clinical >Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression
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Transdiagnostic commonalities and differences in resting state functional connectivity of the default mode network in schizophrenia and major depression

机译：精神分裂症和重度抑郁症的默认模式网络的透诊断共性和静息状态功能连接的差异

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Schizophrenia and depression are prevalent psychiatric disorders, but their underlying neural bases remains poorly understood. Neuroimaging evidence has pointed towards the relevance of functional connectivity aberrations in default mode network (DMN) hubs, dorso-medial prefrontal cortex and precuneus, in both disorders, but commonalities and differences in resting state functional connectivity of those two regions across disorders has not been formally assessed. Here, we took a transdiagnostic approach to investigate resting state functional connectivity of those two regions in 75 patients with schizophrenia and 82 controls from 4 scanning sites and 102 patients with depression and 106 controls from 3 sites. Our results demonstrate common dysconnectivity patterns as indexed by a significant reduction of functional connectivity between precuneus and bilateral superior parietal lobe in schizophrenia and depression. Furthermore, our findings highlight diagnosis-specific connectivity reductions of the parietal operculum in schizophrenia relative to depression. In light of evidence that points towards the importance of the DMN for social cognitive abilities and well documented impairments of social interaction in both patient groups, it is conceivable that the observed transdiagnostic connectivity alterations may contribute to interpersonal difficulties, but this could not be assessed directly in our study as measures of social behavior were not available. Given the operculum's role in somatosensory integration, diagnosis-specific connectivity reductions may indicate a pathophysiological mechanism for basic self-disturbances that is characteristic of schizophrenia, but not depression. Highlights ? Social impairments are well known in schizophrenia (SCZ) and major depressive disorder (MDD). ? We investigated resting state functional connectivity of the default mode network in both patient groups. ? Results demonstrate common fMRI dysconnectivity patterns of precuneus and superior parietal lobe. ? Findings also highlight diagnosis-specific dysconnectivity of the parietal operculum in SCZ. ? Transdiagnostic connectivity alterations may contribute to the social difficulties of both patient groups.
机译：精神分裂症和抑郁症是普遍的精神疾病，但其潜在的神经基础仍知之甚少。神经影像学证据表明，在这两种疾病中，默认模式网络（DMN）集线器，背中前额叶皮层和胎前神经中功能连通性畸变的相关性，但尚未发现这两个区域在疾病中的静止状态功能连通性的共性和差异正式评估。在这里，我们采用了一种跨诊断方法，研究了来自4个扫描部位的75位精神分裂症患者和82位对照，来自3位的102位抑郁症患者和106位对照的这两个区域的静息状态功能连接性。我们的研究结果表明，精神分裂症和抑郁症患者的前足神经和双侧顶叶之间的功能性连接显着减少，从而指示出常见的失联模式。此外，我们的发现突出显示了相对于抑郁症，精神分裂症患者顶盖的特定于诊断的连通性降低。鉴于有证据表明DMN对两个患者组的社会认知能力和社会交往障碍都有重要的记录，可以想象观察到的经诊断性连接改变可能会导致人际交往困难，但这不能直接评估在我们的研究中，由于没有社会行为的量度。考虑到盖在体感整合中的作用，特定于诊断的连通性降低可能表明发生精神分裂症（而非抑郁症）的基本自我困扰的病理生理机制。强调 ？社会障碍在精神分裂症（SCZ）和重度抑郁症（MDD）中是众所周知的。 ？我们调查了两个患者组中默认模式网络的静息状态功能连接性。 ？结果表明，常见的前核和顶上叶的功能磁共振成像不连通性模式。 ？研究结果还突出了SCZ顶盖的特定于诊断的不连通性。 ？经转诊的连通性改变可能导致两个患者群体的社会困难。

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