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首页> 外文期刊>Neurosurgical focus >Dynamic contrast-enhanced magnetic resonance imaging of osseous spine metastasis before and 1 hour after high-dose image-guided radiation therapy
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Dynamic contrast-enhanced magnetic resonance imaging of osseous spine metastasis before and 1 hour after high-dose image-guided radiation therapy

机译：大剂量图像引导放射治疗前后1小时骨性脊柱转移瘤的动态对比增强磁共振成像

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OBJECTIVE High-dose image-guided radiation therapy (HD IGRT) has been instrumental in mitigating some limitations of conventional RT. The recent emergence of dynamic contrast-enhanced (DCE) MRI to investigate tumor physiology can be used to verify the response of human tumors to HD IGRT. The purpose of this study was to evaluate the near-immediate effects of HD IGRT on spine metastases through the use of DCE MRI perfusion studies. METHODS Six patients with spine metastases from prostate, thyroid, and renal cell carcinoma who underwent HD IGRT were studied using DCE MRI prior to and 1 hour after HD IGRT. The DCE perfusion parameters plasma volume (Vp) and vascular permeability (Ktrans) were measured to assess the near-immediate and long-term tumor response. A Mann-Whitney U-test was performed to compare significant changes (at p ≤ 0.05) in perfusion parameters before and after RT. RESULTS The authors observed a precipitous drop in Vp within 1 hour of HD IGRT, with a mean decrease of 65.2%. A significant difference was found between Vp values for before and 1 hour after RT (p ≤ 0.05). No significant change was seen in Vp (p = 0.31) and Ktrans (p = 0.1) from 1 hour after RT to the first follow-up. CONCLUSIONS The data suggest that there is an immediate effect of HD IGRT on the vascularity of spine metastases, as demonstrated by a precipitous decrease in Vp. The DCE MRI studies can detect such changes within 1 hour after RT, and findings are concordant with existing animal models.
机译：目的大剂量图像引导放射治疗（HD IGRT）在减轻常规RT的某些局限性方面发挥了作用。动态对比增强（DCE）MRI研究肿瘤生理学的最新进展可用于验证人类肿瘤对HD IGRT的反应。这项研究的目的是通过使用DCE MRI灌注研究评估HD IGRT对脊柱转移的近乎即时的影响。方法对6例行HD IGRT治疗的前列腺癌，甲状腺癌和肾细胞癌棘突转移患者，在HD IGRT之前和1小时后进行DCE MRI检查。测量DCE灌注参数的血浆容量（V p ）和血管通透性（K trans ），以评估近期和长期的肿瘤反应。进行了Mann-Whitney U检验以比较RT前后灌注参数的显着变化（p≤0.05）。结果作者观察到HD IGRT在1小时内V p 急剧下降，平均下降65.2％。在RT之前和之后1小时的V p 值之间存在显着差异（p≤0.05）。从RT后1小时到第一次随访，V p （p = 0.31）和K trans （p = 0.1）没有明显变化。结论数据表明，HD IGRT对脊柱转移瘤的血管有直接作用，如V p 的急剧下降所证明。 DCE MRI研究可以在RT后1小时内检测到这种变化，并且发现与现有动物模型一致。

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