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首页> 外文期刊>Neuroscience Journal >Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders
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Hippocampal Pathophysiology: Commonality Shared by Temporal Lobe Epilepsy and Psychiatric Disorders

机译：海马病理生理：颞叶癫痫和精神疾病共享的共同点。

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Accumulating evidence points to the association of epilepsy, particularly, temporal lobe epilepsy (TLE), with psychiatric disorders, such as schizophrenia. Among these illnesses, the hippocampus is considered the regional focal point of the brain, playing an important role in cognition, psychosis, and seizure activity and potentially suggesting common etiologies and pathophysiology of TLE and schizophrenia. In the present review, we overview abnormal network connectivity between the dentate gyrus (DG) and the Cornus Ammonis area 3 (CA3) subregions of the hippocampus relative to the induction of epilepsy and schizophrenia. In light of our recent finding on the misguidance of hippocampal mossy fiber projection in the rodent model of schizophrenia, we discuss whether ectopic mossy fiber projection is a commonality in order to evoke TLE as well as symptoms related to schizophrenia.
机译：越来越多的证据表明癫痫病，特别是颞叶癫痫（TLE）与精神疾病，例如精神分裂症有关。在这些疾病中，海马被认为是大脑的区域焦点，在认知，精神病和癫痫发作活动中起着重要作用，并可能提示TLE和精神分裂症的常见病因和病理生理。在当前的审查中，我们概述了齿状回（DG）和海马的山茱Corn Am3区（CA3）子区域之间相对于诱发癫痫和精神分裂症的异常网络连接。鉴于我们最近发现的精神分裂症啮齿动物模型中海马苔藓纤维投射的误导性，我们讨论了异位苔藓纤维投射是否是常见的，以唤起TLE以及与精神分裂症相关的症状。

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