...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurosurgical focus >Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain
【24h】

Deep brain stimulation of the dorsal anterior cingulate cortex for the treatment of chronic neuropathic pain

机译：深部脑刺激前扣带回皮层治疗慢性神经性疼痛

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chronic neuropathic pain is estimated to affect 3%-4.5% of the worldwide population. It is associated with significant loss of productive time, withdrawal from the workforce, development of mood disorders such as depression and anxiety, and disruption of family and social life. Current medical therapeutics often fail to adequately treat chronic neuropathic pain. Deep brain stimulation (DBS) targeting subcortical structures such as the periaqueductal gray, the ventral posterior lateral and medial thalamic nuclei, and the internal capsule has been investigated for the relief of refractory neuropathic pain over the past 3 decades. Recent work has identified the dorsal anterior cingulate cortex (dACC) as a new potential neuromodulation target given its central role in cognitive and affective processing. In this review, the authors briefly discuss the history of DBS for chronic neuropathic pain in the United States and present evidence supporting dACC DBS for this indication. They review existent literature on dACC DBS and summarize important findings from imaging and neurophysiological studies supporting a central role for the dACC in the processing of chronic neuropathic pain. The available neurophysiological and empirical clinical evidence suggests that dACC DBS is a viable therapeutic option for the treatment of chronic neuropathic pain and warrants further investigation.
机译：慢性神经性疼痛估计会影响全球人口的3％-4.5％。它与生产时间的大量浪费，从劳动力中退出，情绪障碍（如抑郁和焦虑）的发展以及家庭和社交生活的中断有关。当前的医学疗法常常不能充分治疗慢性神经性疼痛。在过去的30年中，已经针对针对皮质下结构（例如，导水管周围的灰色，腹侧后外侧和丘脑内侧核以及内囊）的深部脑刺激（DBS）进行了研究，以缓解难治性神经性疼痛。鉴于其在认知和情感加工中的核心作用，最近的工作已将背扣带回皮质（dACC）确定为新的潜在神经调节靶标。在这篇综述中，作者简要讨论了DBS在美国用于慢性神经性疼痛的病史，并提出了支持dACC DBS用于该适应症的证据。他们回顾了有关dACC DBS的现有文献，并总结了影像学和神经生理学研究的重要发现，这些研究支持dACC在慢性神经性疼痛的治疗中起着核心作用。现有的神经生理和经验临床证据表明，dACC DBS是治疗慢性神经性疼痛的可行治疗选择，值得进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号