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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Safety Evaluation of Osun River Water Containing Heavy Metals and Volatile Organic Compounds (VOCs) in Rats
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Safety Evaluation of Osun River Water Containing Heavy Metals and Volatile Organic Compounds (VOCs) in Rats

机译：含有重金属和挥发性有机化合物（VOC）的乌森河水在大鼠中的安全性评估

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This study evaluated the pH, heavy metals and volatile organic compounds (VOCs) in Osun river water. It also evaluated its safety in rats. Heavy metals were determined by atomic absorption spectrophotometry (AAS) while VOCs were determined by gas chromatography coupled with flame ionization detector (GC-FID). Male and female rats were exposed to Osun river water for three weeks and then sacrificed. The abundance of heavy metals in Osun river followed the trend Pb > Cd > Zn > Fe > Cr > Cu while VOCs followed the trend benzene < ethylbenzene < toluene < xylene. The concentrations of Pb, Cd and benzene were higher than the permissible limits of Standards Organization of Nigeria (SON) and World Health Organization (WHO) respectively. Rats exposed to Osun river water for three weeks had increased WBC, thiobarbituric acid reactive substances (TBARS), serum proteins and serum aminotransferases. There were also significant decreases (P < 0.05) in HCT, PLT, liver aminotransferases and liver glutathione compared to the control. These results show that the pollutants in Osun river water are capable of inducing hematological imbalance and liver cell injury. The toxicity induced in blood was sex-dependent affecting female rats more than male rats.
机译：这项研究评估了Osun河水中的pH值，重金属和挥发性有机化合物（VOC）。它还评估了它在大鼠中的安全性。重金属通过原子吸收分光光度法（AAS）测定，而挥发性有机化合物（VOC）通过气相色谱-火焰离子化检测器（GC-FID）进行测定。将雄性和雌性大鼠暴露于Osun河水中三周，然后处死。 Osun河中重金属的含量遵循Pb> Cd> Zn> Fe> Cr> Cu的趋势，而VOCs则遵循苯<乙苯<甲苯<二甲苯的趋势。铅，镉和苯的浓度分别高于尼日利亚标准组织（SON）和世界卫生组织（WHO）的允许限值。暴露于Osun河水中三周的大鼠的WBC，硫代巴比妥酸反应性物质（TBARS），血清蛋白和血清氨基转移酶升高。与对照组相比，HCT，PLT，肝氨基转移酶和肝谷胱甘肽也显着降低（P <0.05）。这些结果表明，奥孙河水中的污染物能够引起血液学失衡和肝细胞损伤。在血液中诱导的毒性比雌性大鼠对雌性大鼠的性别依赖性更大。

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