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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Anti-Gastric Ulcer Effect of Betulinic Acid in Male Albino Rats
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Anti-Gastric Ulcer Effect of Betulinic Acid in Male Albino Rats

机译：桦木酸对雄性白化病大鼠的抗胃溃疡作用

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摘要

Betulinic acid (BA) is a lupane-type triterpene that has been identified and isolated from various plant species used in ethnomedicine in various cultures across the world. This study was undertaken to elucidate the mechanisms underlying the anti-ulcer effect of Betulinic acid. The effect of BA on indomethacin-induced ulcer, gastric mucus secretion, gastric mucus cells count, basal and histamine-induced gastric acid secretion and levels of malondialdehyde formation were studied using dose of 0.5, 1.5, and 3.0 mg/kg. The results showed that BA reduced indomethacin-induced ulceration significantly and significantly increased (p < 0.05) gastric mucus secretion in the 1.5 mg/kg and 3.0 mg/kg BA treated rats compared to the control rats. There was a significant increase (p < 0.05) in the mucus cells count in all the treated groups which is in a dose- dependent manner compared to the control group. There was significant decrease (p < 0.05) in gastric acid secretion in each of the BA treated groups compared to the control. Malondialdehyde concentration significantly decrease (P < 0.05) in all the treated groups compared to the control. The anti-gastric ulcer effect of BA may be mediated via decreasing gastric acid secretion, increasing gastric mucus secretions, increasing the number of gastric mucus cells and also by reducing the level of MDA concentration.
机译：Betulinic acid（BA）是一种Lupane型三萜烯，已从世界各地各种文化中的民族药的各种植物物种中鉴定并分离出来。进行该研究以阐明贝特林酸的抗溃疡作用的潜在机制。用0.5、1.5和3.0 mg / kg的剂量研究了BA对消炎痛诱导的溃疡，胃粘液分泌，胃粘液细胞计数，基础和组胺诱导的胃酸分泌以及丙二醛形成水平的影响。结果表明，与对照大鼠相比，在1.5 mg / kg和3.0 mg / kg BA处理的大鼠中，BA显着减少了消炎痛诱导的溃疡，并且显着增加了（p <0.05）胃粘液分泌。与对照组相比，所有治疗组的粘液细胞计数均显着增加（p <0.05）。与对照组相比，每个BA治疗组的胃酸分泌均显着降低（p <0.05）。与对照组相比，所有处理组的丙二醛浓度均显着降低（P <0.05）。 BA的抗胃溃疡作用可以通过减少胃酸分泌，增加胃粘液分泌，增加胃粘液细胞数量以及降低MDA浓度来介导。

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