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首页> 外文期刊>Nigerian Journal of Physiological Sciences >A Survey of ABO, Rhesus (D) Antigen and Haemoglobin Genes Variants in Oyo State, Nigeria
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A Survey of ABO, Rhesus (D) Antigen and Haemoglobin Genes Variants in Oyo State, Nigeria

机译：尼日利亚奥约州ABO，恒河猴（D）抗原和血红蛋白基因变异的调查

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摘要

A survey of ABO and Rhesus (Rh D) antigens and variants of haemoglobin genes (HbGen) in Oyo state was carried out. This longitudinal study involved the determination of ABO and Rh(D) antigens in 3241 and HbGen in 2622 male and female adults (aged 26-65years) respectively using standard methods. 94.5% of the subjects were Rh(D) positive while 5.5% were Rh(D) negative respectively based on the detection (Positive) or absence (Negative) of Rh(D) antigen. 22.8% of the subjects had ABO blood group A, 26.4% were group B, 4.1% were group AB while 46.7% were group O. Further analysis revealed that 695 (21.4%) of the group A were Apositive while 44 (1.4%) were Anegative. 800 of these subjects (24.7%) were Bpositive while 56 (1.7%) were group Bnegative. 133 (4.1%) showed group AB out of which 125 (3.8%) were ABpositive and 8 (0.3%) were ABnegative. 1513 (46.7%) were group O out of which 1444 (44.6%) were Opositive while 69 (2.1%) were Onegative. HbGen determination showed that 1933 of the subjects (73.7%) had HbGen AA; 553 (21.1%) were AS; 119 (4.5%) were AC; 11 (0.4%) were SC while 3 subjects representing 0.1% and 0.2% each had HbGen SS and CC respectively. Although the results were similar to earlier ones; however, the need for sustained counselling towards eradication of SS genes and increased research towards identifying artificial blood substitutes was highlighted in this work. The increasing need for blood transfusion especially with the increase in various politically/communally motivated emergency situations underscores this fact.
机译：进行了ABO和恒河猴（Rh D）抗原以及Oyo州血红蛋白基因变体（HbGen）的调查。这项纵向研究涉及使用标准方法分别测定2622位男性和女性成年人（26-65岁）的3241和HbGen中的ABO和Rh（D）抗原。根据对Rh（D）抗原的检测（阳性）或不存在（阴性），分别有94.5％的受试者Rh（D）阳性，而5.5％的Rh（D）阴性。 22.8％的受试者为ABO血型A组，B组为26.4％，AB组为4.1％，O组为46.7％。进一步分析显示，A组为695名（21.4％）为阳性，而44组（1.4％）是负面的。这些受试者中有800名（24.7％）为阳性，而56名（1.7％）为阴性组。 133（4.1％）位显示AB组，其中125位（3.8％）为AB阳性，8位（0.3％）为AB阴性。 O组为1513（46.7％），其中正数为1444（44.6％），正数为69（2.1％）。 HbGen的测定显示1933名受试者（73.7％）患有HbGen AA。 AS 553（21.1％）; 119（4.5％）为交流; HbGen SS和CC分别为11名（0.4％）为SC，而分别占0.1％和0.2％的3名受试者分别为HbGen SS和CC。尽管结果与早期的相似;然而，这项工作强调了为消灭SS基因而进行持续咨询以及对鉴定人造血液替代品进行更多研究的需要。尤其是在各种出于政治/社区动机的紧急情况中，对输血的需求不断增加，这凸显了这一事实。

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