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首页> 外文期刊>Nigerian Journal of Physiological Sciences >Effect of Ethanolic Leaf Extract of Senna Fistula on some Haematological Parameters, Lipid Profile and Oxidative Stress in Alloxan-induced Diabetic Rats
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Effect of Ethanolic Leaf Extract of Senna Fistula on some Haematological Parameters, Lipid Profile and Oxidative Stress in Alloxan-induced Diabetic Rats

机译：番泻叶乙醇提取物对四氧嘧啶致糖尿病大鼠血液学参数，脂质分布和氧化应激的影响

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Summary: Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. The disease is also known to adversely affect some haematological parameters and cause dyslipidemia. This study was designed to investigate the effect of chronic administration of ethanolic leave extract of Senna fistula on haematological values, oxidative stress and dyslipidemia in experimental diabetic rats. Twenty-four albino rats weighing 120-150 g were divided into 4 experimental groups of six rats each; control, diabetic untreated, diabetic treated with glibenclamide and diabetic treated with 100 mg/kg b.w of Senna fistula. Diabetes was induced by 100 mg/kg b.w. of alloxan monohydrates. The control and diabetic groups received normal saline while the diabetic treated groups were administered with 5mg/kg and 100mg/kg body weight of glibenclamide and ethanolic leaves extract of Senna fistula respectively for 28 days. At the end of experimental period blood samples were taken from the animals for the determination of Red blood cells (RBC), packed cell volume (PCV), Haemoglobin concentration (Hb), total cholesterol, triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and malondialdehyde (MDA), marker of lipid peroxidation. The result showed that in diabetic rats, PCV, RBC and Hb were decreased but the application of the extract increased the parameters (P&0.05, n=6). Similarly, the result showed a significant increase in total cholesterol, TG and LDL level of the diabetic group when compared with the control, glibenclamide and extract treated diabetic groups, however, there was no significant difference in HDL level in all the groups. The result also showed a significant decrease in elevated MDA (P&0.05, n=6) of diabetic treated rats. These findings suggest that ethanolic leaves extract of Senna fistula might improve the diabetic induced disturbances of some haematological parameters, reduces the plasma lipid imbalances and decreases the production of free radicals associated with diabetes. Keywords: Glibenclamide, Senna Fistula, Diabetes Mellitus, Packed Cell Volume, Malondialdehyde
机译：简介：在实验和临床研究中越来越多的证据表明，氧化应激在两种类型糖尿病的发病机理中都起着重要作用。还已知该疾病不利地影响某些血液学参数并引起血脂异常。本研究旨在研究慢性给予番泻叶乙醇提取物提取物对实验性糖尿病大鼠血液学指标，氧化应激和血脂异常的影响。将24只体重为120-150 g的白化病大鼠分为4组，每组6只。对照，未治疗的糖尿病，使用格列本脲治疗的糖尿病和用100 mg / kg b.w的番泻叶瘘治疗的糖尿病。 100 mg / kg b.w.诱导糖尿病。一水合四氧嘧啶。对照组和糖尿病组接受生理盐水，而糖尿病治疗组分别给予5mg / kg和100mg / kg体重的格列本脲和番泻叶乙醇叶提取物给药28天。在实验期结束时，从动物身上采集血液样本，以确定红细胞（RBC），堆积细胞体积（PCV），血红蛋白浓度（Hb），总胆固醇，甘油三酸酯（TG），高密度脂蛋白（HDL） ），低密度脂蛋白（LDL）和丙二醛（MDA），它们是脂质过氧化的标志。结果表明，在糖尿病大鼠中，PCV，RBC和Hb降低，但提取物的使用增加了参数（P ＜0.05，n ＝ 6）。同样，结果显示，与对照组，格列本脲和提取物治疗的糖尿病组相比，糖尿病组的总胆固醇，TG和LDL水平显着增加，但所有组的HDL水平均无显着差异。该结果还显示糖尿病治疗的大鼠的MDA升高显着降低（P ＜0.05，n ＝ 6）。这些发现表明，番泻叶乙醇叶提取物可能会改善糖尿病引起的某些血液学参数的紊乱，减少血浆脂质失衡，并减少与糖尿病有关的自由基的产生。关键词：格列本脲，番泻叶瘘，糖尿病，细胞堆积，丙二醛

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