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Experimental neuroprotection in ischemic stroke: a concise review

机译:缺血性中风的实验性神经保护作用:简明综述

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Acute ischemic stroke (AIS) is a leading cause of disability and death worldwide. To date, intravenous tissue plasminogen activator and mechanical thrombectomy have been standards of care for AIS. There have been many advances in diagnostic imaging and endovascular devices for AIS; however, most neuroprotective therapies seem to remain largely in the preclinical phase. While many neuroprotective therapies have been identified in experimental models, none are currently used routinely to treat stroke patients. This review seeks to summarize clinical studies pertaining to neuroprotection, as well as the different preclinical neuroprotective therapies, their presumed mechanisms of action, and their future applications in stroke patients.
机译:急性缺血性中风(AIS)是全球致残和死亡的主要原因。迄今为止,静脉内组织纤溶酶原激活剂和机械血栓切除术已成为AIS的护理标准。用于AIS的诊断成像和血管内装置已经取得了许多进步。然而,大多数神经保护疗法似乎仍处于临床前阶段。尽管在实验模型中已经确定了许多神经保护疗法,但目前尚无常规疗法可用于治疗中风患者。这篇综述试图总结与神经保护有关的临床研究,以及不同的临床前神经保护疗法,其推测的作用机制以及它们在中风患者中的未来应用。

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