...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurosurgical focus >Relationship between tumor location, size, and WHO grade in meningioma
【24h】

Relationship between tumor location, size, and WHO grade in meningioma

机译：脑膜瘤的肿瘤位置，大小与WHO分级之间的关系

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE Prior studies have investigated preoperative risk factors for meningioma; however, no association has been shown between meningioma tumor size and tumor grade. The objective of this study was to investigate the relationship between tumor size and grade in a large single-center study of patients undergoing meningioma resection. METHODS A retrospective chart review of patients undergoing meningioma resection at the University of California, San Francisco, between 1985 and 2015 was performed. Patients with incomplete information, spinal meningiomas, multiple meningiomas, or WHO grade III meningiomas were excluded. The largest tumor dimension was used as a surrogate for tumor size. Univariate and multivariate logistic regression models were used to investigate the relationship between tumor grade and tumor size. A recursive partitioning analysis was performed to identify groups at higher risk for atypical (WHO grade II) meningioma. RESULTS Of the 1113 patients identified, 905 (81%) had a WHO grade I tumor and in 208 (19%) the tumors were WHO grade II. The median largest tumor dimension was 3.6 cm (range 0.2–13 cm). Tumors were distributed as follows: skull base (n = 573, 51%), convexity/falx/parasagittal (n = 431, 39%), and other (n = 109, 10%). On univariate regression, larger tumor size (p 6 cm (OR 3.01, 95% CI 1.53–5.94), and convexity/falx/parasagittal location (OR 1.83, 95% CI 1.19–2.82) to be significantly associated with WHO grade II. Recursive partitioning analysis identified male patients with tumors > 3 cm as a high-risk group (32%) for WHO grade II meningioma. CONCLUSIONS Larger tumor size is associated with a greater likelihood of a meningioma being WHO grade II, independent of tumor location and male sex, which are known risk factors.
机译：目的先前的研究已经调查了脑膜瘤的术前危险因素。然而，脑膜瘤的肿瘤大小与肿瘤的分级之间没有关联。这项研究的目的是在一项针对脑膜瘤切除术患者的大型单中心研究中研究肿瘤大小与分级之间的关系。方法回顾性分析了1985年至2015年在加利福尼亚大学旧金山分校进行的脑膜瘤切除术的患者。信息不完整，脊髓性脑膜瘤，多发性脑膜瘤或WHO WHO III级脑膜瘤的患者被排除在外。最大的肿瘤尺寸用作肿瘤尺寸的替代物。使用单因素和多因素逻辑回归模型研究肿瘤等级与肿瘤大小之间的关系。进行递归分区分析以鉴定非典型（WHO II级）脑膜瘤高危人群。结果在确定的1113例患者中，有905例（81％）患有WHO一级肿瘤，在208例（19％）中属于WHO二级肿瘤。中位最大肿瘤尺寸为3.6厘米（范围0.2-13厘米）。肿瘤的分布如下：颅底（n = 573，51％），凸度/ falx /副矢状（n = 431，39％）和其他（n = 109，10％）。单因素回归分析显示，较大的肿瘤尺寸（p 6 cm（OR 3.01，95％CI 1.53–5.94）和凸度/镰状/矢状位（OR 1.83，95％CI 1.19–2.82）与WHO II级显着相关。递归分区分析确定，肿瘤大于3 cm的男性患者是WHO II级脑膜瘤的高危人群（结论）结论肿瘤较大与WHO II级脑膜瘤的可能性更大，而与肿瘤的位置和分布无关。男性，这是已知的危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号