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外文期刊>Kidney International Reports
>P46 LOW DOSE CYCLOPHOSPHAMIDE AS AN INDUCTION AGENT IN PROLIFERATIVE LUPUS NEPHRITIS PATIENTS IN CENTRAL INDIA - AN AFFORDABLE & VIABLE OPTION
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P46 LOW DOSE CYCLOPHOSPHAMIDE AS AN INDUCTION AGENT IN PROLIFERATIVE LUPUS NEPHRITIS PATIENTS IN CENTRAL INDIA - AN AFFORDABLE & VIABLE OPTION
Intrarenal Treg exhibit characteristic signs of IL-2 deprivation in parallel to a progressive hyperactivity of intrarenal Tconwith disease progression. These Treg defects were associated with adiminished production of IL-2 and an increased production of IFNgby kidney-infiltrating Tcon. Furthermore, IL-2 therapy could increase the frequency of intrarenal natural CD25+Helios+Treg,strongly reduced the hyperactivity of intrarenal Tcon, ultimatelyresulted in a reduced histological AI and prolonged the survival ofIL-2 treated lupus mice.
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