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首页> 外文期刊>Kidney Research and Clinical Practice >Apelin in hemodialysis patients: is there relationship with oxidative and inflammation markers?
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Apelin in hemodialysis patients: is there relationship with oxidative and inflammation markers?

机译：血液透析患者的Apelin：与氧化和炎症标志物有关系吗？

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Inflammation and oxidative stress are importante features associated with pathogenesis of cardiovascular disease in hemodialysis (HD) patients. Apelin is a bioactive peptide involved in a variety of physiological functions that has been associated with inflammation, however; little is known about apelin in chronic kidney disease (CKD). Thus, the purpose of this study was to analyse apelin plasma levels in HD patients and verify if there is any relationship with inflammation and oxidative markers. Twenty-four HD patients (53.6+/-14.4 years of age, 14 men and body mass index (BMI) of 25.0+/-4.2kg/m^2) were studied and compared to 15 healthy subjects (51.3+/-13.5 years of age, 7 men and BMI of 26.3+/-3.7kg/m^2). Plasma apelin-12 and -36 were measured using the enzyme immunometric assay (EIA) method. Plasma electronegative low density lipoprotein (LDL-) levels were measured using ELISA method. The levels of tumor-necrosis factor-@a (TNF-@a), interleukin-6, leptin and plasminogen activator inhibitor-1 were measured by a multiplex assay kit and C-reactive protein (CRP) by immunoturbidimetry. There was no difference between apelin-36 levels in HD patients (0.82+/-0.60ng/mL) and healthy subjects (0.83+/-0.23ng/mL). In contrast, apelin-12 levels were significantly higher in patients, 0.34 +/-0.15ng/mL than in healthy subjects, 0.24+/-0.13ng/mL. Inflammation (TNF-@a and CRP) and oxidative markers levels (LDL-) were higher in HD patients (5.4+/-1.3pg/mL, 0.15 (0.33)mg/dL and 0.19+/-0.13U/L, respectively); however, there was not correlation among apelin-12 or -36 and inflammatory or oxidative markers. In conclusion, plasma apelin seems to be not associated with inflammatory and oxidative status in HD patients.
机译：炎症和氧化应激是与血液透析（HD）患者心血管疾病发病机理相关的重要特征。然而，Apelin是一种生物活性肽，可参与多种与炎症相关的生理功能。对于慢性肾病（CKD）中的apelin知之甚少。因此，本研究的目的是分析HD患者的apelin血浆水平，并验证其是否与炎症和氧化标记有关。研究了24名HD患者（53.6 +/- 14.4岁，14名男性，体重指数（BMI）为25.0 +/- 4.2kg / m ^ 2），并将其与15名健康受试者（51.3 +/- 13.5）进行了比较岁以下的男性，7名男性和BMI为26.3 +/- 3.7kg / m ^ 2）。使用酶免疫测定法（EIA）测量血浆apelin-12和-36。血浆负电性低密度脂蛋白（LDL-）水平使用ELISA方法进行测量。肿瘤坏死因子-α（TNF-αa），白介素-6，瘦素和纤溶酶原激活物抑制剂-1的水平通过多重测定试剂盒进行测定，C反应蛋白（CRP）通过免疫比浊法进行测定。 HD患者（0.82 +/- 0.60ng / mL）和健康受试者（0.83 +/- 0.23ng / mL）的apelin-36水平没有差异。相比之下，患者中的apelin-12水平明显高于健康受试者的0.24 +/- 0.13ng / mL，为0.34 +/- 0.15ng / mL。 HD患者的炎症（TNF-αa和CRP）和氧化标志物水平（LDL-）较高（分别为5.4 +/- 1.3pg / mL，0.15（0.33）mg / dL和0.19 +/- 0.13U / L） ）;但是，apelin-12或-36与炎症或氧化标记之间没有相关性。总之，血浆apelin似乎与HD患者的炎症和氧化状态无关。

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