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首页> 外文期刊>North American Journal of Medical Sciences >Histological effects of chronic administration of Phyllanthus amarus on the kidney of adult Wistar rat
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Histological effects of chronic administration of Phyllanthus amarus on the kidney of adult Wistar rat

机译：长期服用mar兰对成年Wistar大鼠肾脏的组织学影响

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Background:Phyllanthus amarus is commonly used for treatment such as in gastro, urogenital diseases and infection. However, it is speculated to have some toxic effects such as renal tubular damage.Aims:This study was to investigate the histological effects of chronic administration of the herb on kidney of adult Wistar rats.Material and Methods:Rats of both sexes (n = 24), with average weight of 200g were randomly assigned into two treatments (A and B) and control (C) groups of 8 rats each. Rats in treatment groups (A) and (B) respectively received daily administration of 400mg and 800mg of aqueous Phyllanthus amarus, per 70kg body weight for 30days through the orogastric tube. The control group received distilled water through the same route. All rats were fed with grower's mash and given water liberally. The rats were sacrificed by cervical dislocation on the thirty-first day of the experiment and the kidneys were carefully dissected out and quickly fixed in 10% formal saline for histological study.Results:The observations indicate that rats in the treated groups showed some varying degree of distortion and disruption in microanatomy of the kidney including interstitial oedema and tubular necrosis, when compared to the control section.Conclusion:This report provides further evidence that medicinal use of Phyllanthus amarus has a potential adverse effect. This warrants further studies to establish or rule out any untoward side-effect of chronic renal dysfunctions.
机译：背景：紫叶楠通常用于治疗胃，泌尿生殖系统疾病和感染等疾病。然而，据推测它具有某些毒性作用，例如肾小管损伤。目的：本研究旨在研究长期服用该药对成年Wistar大鼠肾脏的组织学影响。材料与方法：两性大鼠（n = 24）将平均体重200克的大鼠随机分为两组（A和B）和对照组（C），每组8只。治疗组（A）和（B）中的大鼠分别通过鼻胃管每天服用每70kg体重400mg和800mg的水紫竹，持续给药30天。对照组通过相同途径接受蒸馏水。给所有大鼠喂食生长者的，并自由饮水。在实验的第三十天，通过颈脱位法处死大鼠，仔细解剖肾脏，并迅速将其固定在10％的生理盐水中以进行组织学研究。结果：观察表明，治疗组中的大鼠表现出不同程度的与对照组相比，肾脏的微观解剖结构的扭曲和破坏，包括间质性水肿和肾小管坏死。结论：本报告提供了进一步的证据，证明药用紫竹有潜在的不良作用。这值得进一步研究，以建立或排除慢性肾功能不全的任何不良副作用。

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